Try the following:
During Setup, you may have to restart the computer one or more times. Logging on as a member of the Guests group during the Setup process may result in an installation error. Setup requires that you are logged on as a member of the Administrators group.
If you already have mouse software installed on your computer, you may not be able to install Microsoft Mouse and Keyboard Center until you remove the existing mouse software. Some computer manufacturers pre-install mouse software that is appropriate for the mouse that came with the computer.
Some Microsoft Mouse and Keyboard Center software features may not work with some programs. The programs must be designed to use standard Windows functionality for all of the Microsoft Mouse and Keyboard Center features to work.
Also, in Windows 7 or later, if you open a program using the Run as administrator command, you may not be able to use some Microsoft Mouse and Keyboard Center software features.
You can reassign button (or another button) to Middle Click if you want to use it for this purpose now.
The mouse may be dirty which can impair performance. Try cleaning the mouse.
If you are using a mouse that has an optical sensor, make sure that you are using it on a surface that does not impair performance. The sensor performs best on surfaces with detail to track. It will not function on surfaces without visible detail (such as glass) or surfaces on which it has a reflection (such as mirrors or glossy surfaces). The sensor may also have difficulty tracking on highly repetitive patterns (such as printed magazine or newspaper photographs).
Microsoft Mouse and Keyboard Center software is not supported on switch boxes. If you are using a switch box, some of the Microsoft Mouse and Keyboard Center features, such as scrolling and reassigning buttons, may not work.
Try the following:
Some portable computers use a magnetic field to detect if the lid is closed. If your mouse has a magnetic charging cable, moving this cable too close to your computer may cause your computer to go into standby mode. To avoid this problem, keep your magnetic charging cable away from the portable computer keyboard.
If a rechargeable mouse becomes too hot while charging, the battery indicator light may still flash green, but may not charge. Refer to the Product Guide included with your device to determine normal operating temperatures.
The Microsoft mouse buttons have default assignments when you first use them. Some of these button commands may not work in the program that you are using. For example, the default button assignment for the right button is Right-click, but some programs may not support this command. Try pressing the button while you are using programs that you are sure support the button's command. You can also reassign the button to a different command.
The button may also be assigned to a command that you are not familiar with. You can find out the commands that are assigned to each button by using Microsoft Mouse and Keyboard Center software.
If the wheel does not work in any program that has a scrollable document open (such as Microsoft Internet Explorer), make sure that Microsoft Mouse and Keyboard Center wheel support is enabled:
If scrolling works in some programs (such as Microsoft Word or Internet Explorer) but not in others, even though they have scroll bars, those other programs might not support the scroll wheel.
If a mouse button is assigned to Magnify globally, but you have a different action assigned to that button in a specific program (or vice versa), Microsoft Mouse and Keyboard Center might turn off the Magnifier automatically if you switch from a program where the Magnifier is recognized to one where it is not.
The Magnifier may not correctly display images or video in some applications or games.
If Quick Turn does not calibrate correctly:
Quick Turn may be affected by changes in mouse speed, acceleration, or sensitivity settings. If you change any of these settings, you may have to recalibrate Quick Turn.
Use Program-Specific Settings to save a different Quick Turn for each game you play.