Chev Chelios is a hit man who let his last target slip away in an effort to quit professional killing and start a new life with his girlfriend Eve. But he wakes up the next morning to discover he's been poisoned in his sleep and only has an hour to live. Now, Chev must keep moving to stay alive: the only way to prolong the poison from stopping his heart is to keep his adrenaline flowing. As the clock ticks, Chelios cuts a swath through the streets of Los Angeles, wreaking havoc on those who dare stand in his way. He must rescue Eve from danger, stay two steps ahead of his nemeses and search for an antidote to save his own life.