Academy Award and Golden Globe-nominees Johnny Depp (“Pirates of the Caribbean,” franchise, “Charlie and the Chocolate Factory”) and Academy Award and Golden Globe-winner Charlize Theron (“Monster,” “The Italian Job”) star as the perfect all-American couple--astronaut Spencer Armacost and his beautiful schoolteacher wife--so passionately in love they can sense each other even while he floats in space and she is two hundred thousand miles below. But in two minutes it all turns to inexplicable terror. For two minutes, Armacost completely loses consciousness while on a space mission, returning home just barely alive. His wife senses something amiss from the moment he lands on earth. She begins to have strangely violent dreams--dark, paranoid thoughts--and the sensation that her husband is not the lover, or the man, he was.