After causing the Miskatonic University Massacre, Dr. Herbert West has been serving a prison sentence for the past 14 years. Far from overcoming his scientific obsession with bringing dead organisms back to life, he has had no choice but to continue his experiments on the only specimens he can find in his cell: rats. When Howard, a new young doctor, comes to work as the prison MD and requests his assistance, Dr. West discovers the young protege has something he left behind 14 years ago...