Officer Mike Biggs (Billy Gardell) is a good-hearted cop who sincerely wants to lose weight. Mike's partner, Officer Carl McMillan, is a thin, fast-talking wise-guy who, despite his teasing, encourages Mike on his road to slimness and romance. While speaking at an O.A. meeting, Mike meets Molly Flynn (Melissa McCarthy), an instantly likeable fourth-grade teacher with a good sense of humor about her curves. For Molly, focusing on smart choices isn't easy while living with her sexy older sister, Victoria, and their mother, Joyce (Swoosie Kurtz), both of whom flaunt their effortless figures while indulging their healthy appetites right in front of her. Mike also faces temptation at the diner he and Carl frequent, where they've become friends with a Senegalese waiter, Samuel, to whom dieting is a foreign concept. Mike and Molly found each other in the most unexpected of places. Now, they're about to find out where their quest for companionship will take them.