We show that rigid reachability, the non-symmetric form of rigid E-unification, is already undecidable in the case of a single constraint. From this we infer the undecidability of a new and rather restricted kind of second-order unification. We also show that certain decidable subclasses of the problem which are P-complete in the equational case become EXPTIME-complete when symmetry is absent. By applying automata-theoretic methods, simultaneous monadic rigid reachability with ground rules is shown to be PSPACE-complete. Moreover, we identify two decidable non-monadic fragments that are complete for EXPTIME.