A new algorithm is presented for the automatic segmentation of Multiple Sclerosis (MS) lesions in 3D MR images. It builds on the discriminative random decision forest framework to provide a voxel-wise probabilistic classiﬁcation of the volume. Our method uses multi-channel MR intensities (T1, T2, Flair), spatial prior and long-range comparisons with 3D regions to discriminate lesions. A symmetry feature is introduced accounting for the fact that some MS lesions tend to develop in an asymmetric way. Quantitative evaluation of the data is carried out on publicly available labeled cases from the MS Lesion Segmentation Challenge 2008 dataset and demonstrates improved results over the state of the art.