{"id":1074438,"date":"2022-02-16T20:34:00","date_gmt":"2022-02-17T04:34:00","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-blog-post&#038;p=1074438"},"modified":"2024-09-25T21:17:46","modified_gmt":"2024-09-26T04:17:46","slug":"2021-fellowship-dianyu-chen","status":"publish","type":"msr-blog-post","link":"https:\/\/www.microsoft.com\/en-us\/research\/articles\/2021-fellowship-dianyu-chen\/","title":{"rendered":"\u5fae\u8f6f\u5b66\u8005 | \u897f\u6e56\u5927\u5b66\u9648\u94bf\u96e8\uff1a\u751f\u547d\u79d1\u5b66\u7684\u535a\u58eb\u751f\uff0c\u662f\u600e\u4e48\u6458\u5f97\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u7684\uff1f"},"content":{"rendered":"\n<p>\u7f16\u8005\u6309\uff1a\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u662f\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\u81ea 1999 \u5e74\u542f\u52a8\u7684\u4e00\u9879\u9762\u5411\u4e9a\u592a\u5730\u533a\u8ba1\u7b97\u673a\u79d1\u5b66\u4ee5\u53ca\u76f8\u5173\u4e13\u4e1a\u548c\u4ea4\u53c9\u5b66\u79d1\u7684\u4f18\u79c0\u535a\u58eb\u751f\u7684\u9879\u76ee\uff0c\u8be5\u5956\u5b66\u91d1\u9879\u76ee\u65e8\u5728\u53d1\u6398\u4f18\u79c0\u3001\u6709\u6f5c\u529b\u7684\u4f4e\u5e74\u7ea7\u535a\u58eb\u751f\uff0c\u652f\u6301\u3001\u9f13\u52b1\u5176\u66f4\u597d\u5730\u5f00\u5c55\u7814\u7a76\u5de5\u4f5c\u30022021 \u5e74\uff0c\u6765\u81ea\u4e9a\u592a\u5730\u533a\u7684 11 \u540d\u4f18\u79c0\u535a\u58eb\u751f\u6700\u7ec8\u88ab\u6388\u4e88 2021 \u5e74\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u79f0\u53f7\uff0c\u53e6\u6709 17 \u540d\u535a\u58eb\u751f\u83b7\u5f97\u63d0\u540d\u5956\u3002\u6765\u81ea\u897f\u6e56\u5927\u5b66\u7684\u9648\u94bf\u96e8\u5c31\u662f\u5176\u4e2d\u4e4b\u4e00\uff0c\u4ed6\u4e5f\u662f\u5c11\u6570\u975e\u8ba1\u7b97\u673a\u4e13\u4e1a\u80cc\u666f\u7684\u5f97\u5956\u4eba\u4e4b\u4e00\u3002<\/p>\n\n\n\n<p>\uff08\u672c\u6587\u7f16\u8f91\u81ea\u201c\u897f\u6e56\u5927\u5b66 WestlakeUniversity\u201d\u516c\u4f17\u53f7\uff09<\/p>\n\n\n\n<p>\u9648\u94bf\u96e8\uff0c\u897f\u6e56\u5927\u5b66 2020 \u7ea7\u535a\u58eb\u7814\u7a76\u751f\uff0c\u6765\u81ea\u7cfb\u7edf\u514d\u75ab\u5b66\u5b9e\u9a8c\u5ba4\u3002<\/p>\n\n\n\n<p>\u5c31\u5728\u521a\u521a\u8fc7\u53bb\u7684 2021 \u5e74\uff0c\u4ed6\u6210\u4e3a\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u83b7\u5f97\u8005\u3002\u8fd9\u540d\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684 90 \u540e\uff0c\u4e3a\u4f55\u4f1a\u83b7\u5f97\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\u7684\u9752\u7750\uff0c\u65a9\u83b7\u6b64\u4efd\u6b8a\u8363\uff1f<\/p>\n\n\n\n<p>\u201c\u6211\u5e0c\u671b\u5229\u7528\u8ba1\u7b97\u751f\u7269\u5b66\u65b9\u6cd5\u52a0\u6df1\u6211\u4eec\u5bf9\u4f53\u6db2\u514d\u75ab\u7684\u7406\u89e3\uff0c\u4ece\u800c\u4e3a\u75ab\u82d7\u7814\u53d1\u63d0\u4f9b\u65b0\u7684\u601d\u8def\uff0c\u4e3a\u514d\u75ab\u76f8\u5173\u75be\u75c5\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u9776\u70b9\u3002\u201d<\/p>\n\n\n\n<p>\u8fd9\u662f\u9648\u94bf\u96e8\u5173\u4e8e\u79d1\u7814\u8bbe\u60f3\u7684\u9648\u8ff0\uff0c\u8ba9\u4eba\u5fc3\u52a8\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"732\" height=\"749\" src=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72471.png\" alt=\"\u9648\u94bf\u96e8\u83b7\u5f97 2021 \u5e74\u201c\u5fae\u8f6f\u5b66\u8005\u201d\" class=\"wp-image-1074480\" srcset=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72471.png 732w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72471-293x300.png 293w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72471-176x180.png 176w\" sizes=\"auto, (max-width: 732px) 100vw, 732px\" \/><figcaption class=\"wp-element-caption\">\u9648\u94bf\u96e8\u83b7\u5f97 2021 \u5e74\u201c\u5fae\u8f6f\u5b66\u8005\u201d<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u79d1\u666e-\u9648\u94bf\u96e8\u7684-\u653e\u5927\u955c\">\u79d1\u666e\uff1a\u9648\u94bf\u96e8\u7684\u201c\u653e\u5927\u955c\u201d<\/h2>\n\n\n\n<p>\u968f\u7740\u8fd1\u5e74\u6765\u6570\u636e\u83b7\u53d6\u3001\u5904\u7406\u4e0e\u4eba\u5de5\u667a\u80fd\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u8ba1\u7b97\u673a\u6280\u672f\u5728\u57fa\u7840\u79d1\u5b66\u7684\u7814\u7a76\u4e2d\u4e5f\u626e\u6f14\u7740\u6108\u53d1\u91cd\u8981\u7684\u4f5c\u7528\uff1b\u4eba\u7c7b\u793e\u4f1a\u5f53\u4e0b\u6240\u9762\u4e34\u7684\u5171\u540c\u95ee\u9898\u548c\u5de8\u5927\u6311\u6218\uff0c\u4e5f\u8feb\u5207\u5730\u9700\u8981\u57fa\u7840\u79d1\u5b66\u7814\u7a76\u4e0e\u8ba1\u7b97\u673a\u5b66\u79d1\u6709\u66f4\u52a0\u7d27\u5bc6\u7684\u4ea4\u53c9\u4e0e\u878d\u5408\u3002<strong>\u57fa\u4e8e\u8fd9\u4e00\u8d8b\u52bf\u548c\u9700\u6c42\uff0c\u4e3a\u66f4\u597d\u5730\u53d1\u6398\u5728\u57fa\u7840\u79d1\u5b66\u7814\u7a76\u4e2d\u901a\u8fc7\u8ba1\u7b97\u673a\u7406\u8bba\u4e0e\u6280\u672f\u521b\u65b0\u63a8\u52a8\u672c\u9886\u57df\u53d1\u5c55\u7684\u590d\u5408\u5b66\u672f\u4eba\u624d\uff0c\u652f\u6301\u548c\u9f13\u52b1\u6709\u6f5c\u529b\u7684\u5b66\u751f\u66f4\u597d\u5730\u5f00\u5c55\u4ea4\u53c9\u9886\u57df\u7814\u7a76\u5de5\u4f5c\uff0c2021 \u5e74\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u7ee7\u7eed\u9762\u5411\u201c\u8ba1\u7b97\u79d1\u5b66\u201d\u9886\u57df\u63a5\u6536\u7533\u8bf7\u3002<\/strong><\/p>\n\n\n\n<p>\u9648\u94bf\u96e8\u4e13\u653b\u7684\u8ba1\u7b97\u751f\u7269\u5b66\uff0c\u6b63\u662f\u5c06\u8ba1\u7b97\u601d\u7ef4\u548c\u65b9\u6cd5\u5e94\u7528\u4e8e\u751f\u547d\u79d1\u5b66\u7814\u7a76\u7684\u4e00\u95e8\u5b66\u79d1\u3002\u5b83\u5c06\u6570\u636e\u5206\u6790\u3001\u6570\u5b66\u5efa\u6a21\u548c\u8ba1\u7b97\u673a\u4eff\u771f\u7b49\u5de5\u5177\u5f15\u5165\u751f\u7269\u5b66\u9886\u57df\uff0c\u91cd\u5851\u4e86\u751f\u7269\u5b66\u7814\u7a76\u7684\u65b9\u5f0f\uff0c\u5e76\u62d3\u5c55\u4e86\u751f\u7269\u5b66\u9886\u57df\u3002<\/p>\n\n\n\n<p>\u4f53\u6db2\u514d\u75ab\uff0c\u5219\u96b6\u5c5e\u4eba\u4f53\u7684\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u4e3b\u8981\u7531 B \u7ec6\u80de\u4ecb\u5bfc\uff0c\u662f\u673a\u4f53\u62b5\u5fa1\u75c5\u539f\u5fae\u751f\u7269\u611f\u67d3\u7684\u91cd\u8981\u9632\u7ebf\u3002\u5f53 B \u7ec6\u80de\u53d7\u5230\u6297\u539f\u523a\u6fc0\u540e\uff0c\u80fd\u591f\u8fc5\u901f\u6d3b\u5316\u589e\u6b96\u5e76\u5206\u5316\u4e3a\u6d46\u7ec6\u80de\uff0c\u4ea7\u751f\u5927\u91cf\u6297\u4f53\uff0c\u7279\u5f02\u6027\u5730\u7ed3\u5408\u5e76\u6e05\u9664\u6297\u539f\u3002<\/p>\n\n\n\n<p>\u8fd9\u4e2a\u8fc7\u7a0b\u975e\u5e38\u5feb\u901f\uff0c\u4e00\u822c\u4ec5\u8017\u65f6\u5341\u51e0\u5929\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u6211\u4eec\u8eab\u4f53\u5fae\u89c2\u5c42\u9762 B \u7ec6\u80de\u7684\u5c0f\u4e16\u754c\u91cc\uff0c\u4e5f\u53d1\u751f\u7740\u5982\u540c\u8fbe\u5c14\u6587\u8fdb\u5316\u8bba\u4e00\u822c\u7684\u201c\u6f14\u53d8\u201d\u3002B \u7ec6\u80de\u7684\u8fd9\u4e2a\u201c\u5fae\u578b\u8fdb\u5316\u7cfb\u7edf\u201d\uff0c\u6b63\u662f\u9648\u94bf\u96e8\u6240\u5728\u5b9e\u9a8c\u5ba4\u91cd\u70b9\u653b\u5173\u7684\u65b9\u5411\u4e4b\u4e00\u3002\u4ed6\u4eec\u60f3\u8981\u641e\u61c2\u5176\u4e2d\u7684\u673a\u7406\u2014\u2014\u662f\u4ec0\u4e48\u80de\u5185\u5206\u5b50\u4fe1\u53f7\u5728\u9a71\u52a8 B \u7ec6\u80de\u7684\u6b63\u5411\u7b5b\u9009\uff1f<\/p>\n\n\n\n<p><strong>\u90a3\u8ba1\u7b97\u673a\u79d1\u5b66\u4e3a\u4f55\u4e0e\u4e4b\u76f8\u5173\uff1f<\/strong>\u9648\u94bf\u96e8\u89e3\u91ca\uff1a\u201c\u5728\u8fd9\u6837\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u80fd\u591f\u4ece\u5927\u91cf\u7684\u3001\u9ad8\u590d\u6742\u5ea6\u7684\u5b9e\u9a8c\u6570\u636e\u4e2d\u6316\u6398\u51fa\u9690\u85cf\u7684\u6a21\u5f0f\uff0c\u5f62\u6210\u5047\u8bbe\uff0c\u4e3a\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u9a8c\u8bc1\u63d0\u4f9b\u6307\u5bfc\u3002\u201d<\/p>\n\n\n\n<p>\u7b80\u5355\u7406\u89e3\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u80fd\u591f\u66f4\u597d\u5730\u5e2e\u6211\u4eec\u8fdb\u884c\u751f\u7269\u76f8\u5173\u7684\u6570\u636e\u5904\u7406\u4e0e\u7b5b\u9009\uff0c\u5c31\u50cf\u4e00\u4e2a\u201c\u653e\u5927\u955c\u201d\uff0c\u8ba9\u6211\u4eec\u5728\u7ec6\u679d\u672b\u8282\u4e0a\u770b\u6e05\u695a B \u7ec6\u80de\u514d\u75ab\u6f14\u5316\u7684\u8fc7\u7a0b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u5b9e\u8df5-\u811a\u8e0f\u5b9e\u5730-\u4ef0\u671b\u661f\u7a7a\">\u5b9e\u8df5\uff1a\u811a\u8e0f\u5b9e\u5730\uff0c\u4ef0\u671b\u661f\u7a7a<\/h2>\n\n\n\n<p>\u9648\u94bf\u96e8\u5728\u672c\u6b21\u5fae\u8f6f\u5956\u5b66\u91d1\u7533\u8bf7\u4e2d\u63d0\u4ea4\u7684\u65b9\u5411\uff0c\u5e76\u975e\u201c\u7eb8\u4e0a\u8c08\u5175\u201d\u3002<\/p>\n\n\n\n<p>2021 \u5e74 5 \u6708\uff0c\u5728\u5f00\u59cb\u535a\u58eb\u9636\u6bb5\u5b66\u4e60 9 \u4e2a\u6708\u540e\uff0c\u4ed6\u4f5c\u4e3a\u5171\u540c\u4e00\u4f5c\u7f72\u540d\u7684\u7814\u7a76\u6587\u7ae0\u201cCoupled analysis of transcriptome and BCR mutations reveals role of OXPHOSin affinity maturation\u201d\u53d1\u8868\u4e8e\u671f\u520a Nature Immunology\uff08\u897f\u6e56\u5927\u5b66\u5f90\u548c\u5e73\u7814\u7a76\u5458\u548c\u5339\u5179\u5821\u5927\u5b66 Harinder Singh \u6559\u6388\u4e3a\u8bba\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u5171\u540c\u4e00\u4f5c\u4f5c\u8005\u8fd8\u6709\u897f\u6e56\u5927\u5b66\u535a\u58eb\u751f\u738b\u7430\u548c\u5339\u5179\u5821\u5927\u5b66\u535a\u58eb\u540e Godhev K Manakkat Vijay\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"438\" src=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72472-1024x438.png\" alt=\"diagram\" class=\"wp-image-1074483\" srcset=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72472-1024x438.png 1024w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72472-300x128.png 300w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72472-768x329.png 768w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72472-240x103.png 240w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72472.png 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u627e\u5230\u4e86 B \u7ec6\u80de\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u7684\u201c\u4e24\u4e2a\u4e00\u201d\uff1a\u4e00\u6761\u8be5\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u901a\u8def\u2014\u2014\u6c27\u5316\u78f7\u9178\u5316\u901a\u8def\uff0c\u548c\u4e00\u4e2a\u201c\u795e\u5947\u201d\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u2014\u2014oltipraz\u3002<\/p>\n\n\n\n<p>\u9648\u94bf\u96e8\u8bf4\uff1a\u201c\u4f9d\u8d56\u4e8e\u5305\u62ec\u53cc\u5149\u5b50\u6210\u50cf\u7b49\u6280\u672f\u7684\u8fdb\u5c55\uff0c\u8fc7\u53bb 10 \u5e74\uff0c\u5728\u7ec6\u80de\u5c42\u9762\uff0c\u6211\u4eec\u5bf9 B \u7ec6\u80de\u2018\u8fdb\u5316\u2019\u8fc7\u7a0b\u6709\u4e86\u66f4\u591a\u7684\u8ba4\u77e5\uff0c\u5373\u4e86\u89e3\u4e86\u6709\u54ea\u4e9b\u7ec6\u80de\u53c2\u4e0e\u8fd9\u4e2a\u8fc7\u7a0b\uff1b\u4f46\u5728\u5206\u5b50\u5c42\u9762\uff0c\u4e5f\u5c31\u662f\u5728\u57fa\u56e0\u65b9\u9762\uff0c\u6211\u4eec\u8fd8\u77e5\u4e4b\u751a\u5c11\u3002\u5982\u679c\u60f3\u8981\u77e5\u9053\u54ea\u4e9b\u57fa\u56e0\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u626e\u6f14\u4e86\u91cd\u8981\u89d2\u8272\uff0c\u9996\u5148\u6211\u4eec\u9700\u8981\u4e00\u4e2a\u80fd\u591f\u6709\u6548\u533a\u5206\u4e0d\u540c\u4eb2\u548c\u529b B \u7ec6\u80de\u7684\u6807\u8bb0\u3002\u201d<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72473-1024x682.png\" alt=\"\u9648\u94bf\u96e8\" class=\"wp-image-1074486\" srcset=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72473-1024x682.png 1024w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72473-300x200.png 300w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72473-768x512.png 768w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72473-240x160.png 240w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72473.png 1040w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u501f\u7531\u4e3b\u9898\u6a21\u578b\u65b9\u6cd5\u4e3a\u4ee3\u8868\u7684\u8ba1\u7b97\u5206\u6790\u7684\u201c\u773c\u775b\u201d\uff0c\u9648\u94bf\u96e8\u770b\u5230\u4e86\u4e00\u6761\u5173\u952e\u901a\u8def\uff1a\u6c27\u5316\u78f7\u9178\u5316\u901a\u8def\u3002\u901a\u8def\uff0c\u5373\u4e00\u7ec4\u57fa\u56e0\u901a\u8fc7\u76f8\u4e92\u4f5c\u7528\u884c\u4f7f\u7279\u5b9a\u7684\u529f\u80fd\uff0c\u53ef\u4ee5\u7406\u89e3\u4e3a\u5982\u540c\u7535\u8def\u7684\u4e00\u7cfb\u5217\u201c\u89e6\u53d1\u7ebf\u8def\u201d\uff0c\u5728\u201c\u89e6\u53d1\u201d\u540e\u80fd\u591f\u53d1\u6325\u529f\u7528\u3002\u9648\u94bf\u96e8\u4ed6\u4eec\u53d1\u73b0\uff0c\u5728\u9ad8\u4eb2\u548c\u529b\u7684\u7ec6\u80de\u4e2d\uff0c\u6c27\u5316\u78f7\u9178\u5316\u901a\u8def\u7684\u6d3b\u6027\u4f1a\u66f4\u9ad8\uff08\u4e5f\u5c31\u662f\u57fa\u56e0\u8868\u8fbe\u66f4\u6d3b\u8dc3\uff09\u3002<\/p>\n\n\n\n<p>\u540c\u65f6\uff0c\u4ed6\u4eec\u627e\u5230\u4e86\u4e00\u4e2a\u91cd\u8981\u7684\u5c0f\u5206\u5b50\uff1aoltipraz\u3002\u8fd9\u4e2a\u5c0f\u5206\u5b50\u80fd\u591f\u589e\u5f3a\u6c27\u5316\u78f7\u9178\u5316\u901a\u8def\u7684\u6d3b\u6027\uff0c\u4f7f\u5f97\u673a\u4f53\u66f4\u5feb\u4ea7\u751f\u9ad8\u4eb2\u548c\u529b\u7684\u7ec6\u80de\u3002\u8fd9\u4e5f\u662f\u79d1\u7814\u9886\u57df\u7b2c\u4e00\u4e2a\u88ab\u62a5\u9053\u5177\u6709\u4fc3\u8fdb B \u7ec6\u80de\u7684\u6b63\u5411\u7b5b\u9009\u548c\u6297\u4f53\u4eb2\u548c\u529b\u6210\u719f\u529f\u80fd\u7684\u5316\u5b66\u5c0f\u5206\u5b50\u3002<\/p>\n\n\n\n<p>\u201c\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u5927\u5bb6\u6253\u4e86\u75ab\u82d7\u4ee5\u540e\uff0c\u5c31\u7b49\u5f85\u673a\u4f53\u81ea\u5df1\u4f5c\u5e94\u7b54\u3002\u6709\u7684\u4eba\u53ef\u80fd\u4f1a\u5e94\u7b54\uff0c\u6709\u7684\u4eba\u5374\u6253\u5b8c\u75ab\u82d7\u540e\u4e5f\u4e0d\u4f1a\u4ea7\u751f\u4ec0\u4e48\u6297\u4f53\u2014\u2014\u4e5f\u5c31\u662f\u8bf4\uff0c\u5b8c\u5168\u53d6\u51b3\u4e8e\u4e2a\u4f53\u672c\u8eab\u3002\u90a3\u4e48\uff0c<strong>\u6709\u4e86\u8fd9\u6837\u7684\u5c0f\u5206\u5b50\u540e\uff0c\u6211\u4eec\u5c31\u6709\u53ef\u80fd\u53ef\u4ee5\u4eba\u4e3a\u5e72\u9884\u8fd9\u4e2a\u8fc7\u7a0b\uff0c\u52a0\u901f\u8eab\u4f53\u4ea7\u751f\u6297\u4f53\u3002<\/strong>\u201d<\/p>\n\n\n\n<p>\u8fd9\u4e9b\u53d1\u73b0\u8ba9\u4ed6\u4eec\u9ad8\u5ea6\u5174\u594b\u3002\u6570\u6708\u540e\uff0c\u9648\u94bf\u96e8\u7684\u540d\u5b57\u518d\u6b21\u51fa\u73b0\u5728\u4e86\u53e6\u4e00\u672c\u91cd\u8981\u671f\u520a Immunity \u4e0a\u2014\u201410 \u6708 8 \u65e5\uff0c\u897f\u6e56\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u5f90\u548c\u5e73\u8bfe\u9898\u7ec4\u4e0e\u4f55\u4e39\u9633\u8bfe\u9898\u7ec4\u5728 Immunity \u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u9898\u4e3a\u201cEarly developing B cellsundergo negative selection by central nervous system-specific antigens in themeninges\u201d\u7684\u7814\u7a76\u8bba\u6587\uff0c\u63ed\u793a\u4e86\u4e00\u6761 B \u6dcb\u5df4\u7ec6\u80de\u5728\u8111\u819c\u4e2d\u8fdb\u884c\u53d1\u80b2\u548c\u9634\u6027\u7b5b\u9009\u7684\u5168\u65b0\u9014\u5f84\u2014\u2014<strong>\u9648\u94bf\u96e8\u518d\u6b21\u6210\u4e3a\u6587\u7ae0\u7684\u5171\u4e00\u4f5c\u8005\u4e4b\u4e00\uff0c\u800c\u8fd9\u9879\u6210\u679c\u5728\u540c\u884c\u4e2d\u5f97\u5230\u4e86\u5f88\u9ad8\u7684\u8bc4\u4ef7\u3002<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"950\" height=\"660\" src=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72474.png\" alt=\"diagram\" class=\"wp-image-1074489\" srcset=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72474.png 950w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72474-300x208.png 300w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72474-768x534.png 768w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72474-240x167.png 240w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u76ee\u6807-\u7ee7\u7eed\u7784\u51c6\u514d\u75ab\u8bb0\u5fc6\">\u76ee\u6807\uff1a\u7ee7\u7eed\u7784\u51c6\u514d\u75ab\u8bb0\u5fc6<\/h2>\n\n\n\n<p>\u4f5c\u4e3a\u4e00\u4e2a\u5178\u578b\u7684\u201c\u79d1\u7814\u6d3e\u201d\uff0c\u9648\u94bf\u96e8\u5b8c\u5168\u9002\u5e94\u5e76\u4eab\u53d7\u7740\u5728\u897f\u6e56\u5927\u5b66\u7684\u5b9e\u9a8c\u5ba4\u751f\u6d3b\uff1a\u6bcf\u5929\u4e5d\u70b9\u5de6\u53f3\u8fdb\u5165\u5b9e\u9a8c\u5ba4\uff0c\u5b5c\u5b5c\u4e0d\u5026\u5730\u4e50\u5728\u5176\u4e2d\uff0c\u76f4\u5230\u665a\u4e0a\u5341\u70b9\u518d\u544a\u522b\u3002<\/p>\n\n\n\n<p>\u8fdb\u5165\u535a\u58eb\u9636\u6bb5\u77ed\u77ed\u4e00\u5e74\u591a\uff0c\u5c31\u201c\u521d\u6218\u544a\u6377\u201d\uff0c\u9648\u94bf\u96e8\u7684\u201c\u79d8\u8bc0\u201d\u662f\u4ec0\u4e48\uff1f<\/p>\n\n\n\n<p><strong>\u201c\u6ca1\u6709\u2018\u79d8\u8bc0\u2019\uff01\u5982\u679c\u4e00\u5b9a\u8981\u8bf4\u6709\uff0c\u90a3\u5c31\u662f\u6211\u5f88\u65e9\u5c31\u60f3\u597d\u4e86\u8981\u8d70\u8fd9\u6761\u8def\uff01\u201d<\/strong><\/p>\n\n\n\n<p>\u9648\u94bf\u96e8\u662f\u5b81\u6ce2\u4eba\uff0c\u672c\u7855\u90fd\u5c31\u8bfb\u4e8e\u6d59\u6c5f\u5927\u5b66\u751f\u7269\u4fe1\u606f\u5b66\uff0c\u4ed6\u5f88\u65e9\u5c31\u89c4\u5212\u597d\u4e86\u81ea\u5df1\u672a\u6765\u7684\u8def\uff1a\u8bfb\u535a\u3002\u5728\u4e0e\u76f8\u5173\u9886\u57df\u7684\u51e0\u4f4d\u535a\u5bfc\u4ea4\u6d41\u540e\uff0c\u9648\u94bf\u96e8\u6700\u7ec8\u8fdb\u5165\u4e86\u897f\u6e56\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u535a\u5bfc\u5f90\u548c\u5e73\u8001\u5e08\u7684\u5b9e\u9a8c\u5ba4\uff0c\u7ed3\u5408\u8ba1\u7b97\u751f\u7269\u5b66\u624b\u6bb5\uff0c\u5f00\u542f\u4e86\u5bf9\u514d\u75ab\u5b66\u7684\u7814\u7a76\u3002<\/p>\n\n\n\n<p>\u201c\u6211\u53d1\u73b0\u5f90\u8001\u5e08\u5bf9\u5b9e\u9a8c\u5ba4\u7684\u6784\u60f3\u3001\u7814\u7a76\u65b9\u5411\uff0c\u8ddf\u6211\u60f3\u7684\u90fd\u6bd4\u8f83\u543b\u5408\u3002\u4ed6\u4f1a\u7ed3\u5408\u8ba1\u7b97\u751f\u7269\u5b66\u7684\u624b\u6bb5\u6765\u7814\u7a76\u514d\u75ab\u5b66\u7684\u8bfe\u9898\u3002\u800c\u6211\u5728\u535a\u58eb\u9636\u6bb5\u60f3\u505a\u4e00\u4e9b\u6570\u636e\u5206\u6790\u4e0e\u5b9e\u9a8c\u9a8c\u8bc1\u76f8\u7ed3\u5408\u7684\u8bfe\u9898\uff0c\u5f90\u8001\u5e08\u975e\u5e38\u652f\u6301\u6211\u7684\u60f3\u6cd5\u3002\u201d\u9648\u94bf\u96e8\u8bf4\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72475-768x512-1.png\" alt=\"a group of people posing for a photo\" class=\"wp-image-1074492\" srcset=\"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72475-768x512-1.png 768w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72475-768x512-1-300x200.png 300w, https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2022\/02\/\u56fe\u72475-768x512-1-240x160.png 240w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><figcaption class=\"wp-element-caption\">\u9648\u94bf\u96e8\u6240\u5728\u5b9e\u9a8c\u5ba4\u5408\u7167<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5bf9\u4e8e\u83b7\u5f97\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\uff0c\u9648\u94bf\u96e8\u8ba4\u4e3a\u8fd9\u5c06\u6210\u4e3a\u4ed6\u5b66\u672f\u751f\u6daf\u7684\u5168\u65b0\u8d77\u70b9\uff0c<strong>\u201c\u8fd9\u65e2\u662f\u5bf9\u6211\u8fc7\u53bb\u5de5\u4f5c\u7684\u8ba4\u53ef\uff0c\u4e5f\u589e\u5f3a\u4e86\u6211\u5bf9\u672a\u6765\u79d1\u7814\u63a2\u7d22\u7684\u4fe1\u5fc3\u3002\u201d<\/strong><\/p>\n\n\n\n<p>\u5173\u4e8e\u672a\u6765\uff0c\u8fd9\u4f4d\u5e74\u8f7b\u7684\u79d1\u7814\u5de5\u4f5c\u8005\u601d\u8def\u6e05\u6670\uff1a\u201c\u6211\u5e0c\u671b\u901a\u8fc7\u535a\u58eb\u8fd9\u4e00\u9636\u6bb5\u7684\u5b66\u4e60\u548c\u8bad\u7ec3\uff0c\u80fd\u591f\u6210\u957f\u4e3a\u4e00\u540d\u72ec\u7acb\u7684\u3001\u5408\u683c\u7684 scientist\u3002\u5bf9\u4e8e\u7814\u7a76\u7684\u65b9\u5411\uff0c\u76ee\u524d\u4e3b\u8981\u805a\u7126\u4e8e\u514d\u75ab\u8bb0\u5fc6\uff0c\u63a2\u7d22 B \u7ec6\u80de\u5728\u53d1\u80b2\u548c\u4eb2\u548c\u529b\u6210\u719f\u540e\u7684\u547d\u8fd0\u51b3\u5b9a\u673a\u5236\u3002\u201d<\/p>\n\n\n\n<p>\u5b9e\u9645\u4e0a\uff0c\u9648\u94bf\u96e8\u7684\u7406\u60f3\u4ece\u672a\u53d8\u8fc7\u2014\u2014\u9075\u5faa\u81ea\u5df1\u7684\u5174\u8da3\uff0c\u4e0d\u65ad\u63a2\u7d22\u672a\u77e5\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f16\u8005\u6309\uff1a\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u662f\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\u81ea 1999 \u5e74\u542f\u52a8\u7684\u4e00\u9879\u9762\u5411\u4e9a\u592a\u5730\u533a\u8ba1\u7b97\u673a\u79d1\u5b66\u4ee5\u53ca\u76f8\u5173\u4e13\u4e1a\u548c\u4ea4\u53c9\u5b66\u79d1\u7684\u4f18\u79c0\u535a\u58eb\u751f\u7684\u9879\u76ee\uff0c\u8be5\u5956\u5b66\u91d1\u9879\u76ee\u65e8\u5728\u53d1\u6398\u4f18\u79c0\u3001\u6709\u6f5c\u529b\u7684\u4f4e\u5e74\u7ea7\u535a\u58eb\u751f\uff0c\u652f\u6301\u3001\u9f13\u52b1\u5176\u66f4\u597d\u5730\u5f00\u5c55\u7814\u7a76\u5de5\u4f5c\u30022021 \u5e74\uff0c\u6765\u81ea\u4e9a\u592a\u5730\u533a\u7684 11 \u540d\u4f18\u79c0\u535a\u58eb\u751f\u6700\u7ec8\u88ab\u6388\u4e88 2021 \u5e74\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u79f0\u53f7\uff0c\u53e6\u6709 17 \u540d\u535a\u58eb\u751f\u83b7\u5f97\u63d0\u540d\u5956\u3002\u6765\u81ea\u897f\u6e56\u5927\u5b66\u7684\u9648\u94bf\u96e8\u5c31\u662f\u5176\u4e2d\u4e4b\u4e00\uff0c\u4ed6\u4e5f\u662f\u5c11\u6570\u975e\u8ba1\u7b97\u673a\u4e13\u4e1a\u80cc\u666f\u7684\u5f97\u5956\u4eba\u4e4b\u4e00\u3002 \uff08\u672c\u6587\u7f16\u8f91\u81ea\u201c\u897f\u6e56\u5927\u5b66 WestlakeUniversity\u201d\u516c\u4f17\u53f7\uff09 \u9648\u94bf\u96e8\uff0c\u897f\u6e56\u5927\u5b66 2020 \u7ea7\u535a\u58eb\u7814\u7a76\u751f\uff0c\u6765\u81ea\u7cfb\u7edf\u514d\u75ab\u5b66\u5b9e\u9a8c\u5ba4\u3002 \u5c31\u5728\u521a\u521a\u8fc7\u53bb\u7684 2021 \u5e74\uff0c\u4ed6\u6210\u4e3a\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u83b7\u5f97\u8005\u3002\u8fd9\u540d\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684 90 \u540e\uff0c\u4e3a\u4f55\u4f1a\u83b7\u5f97\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\u7684\u9752\u7750\uff0c\u65a9\u83b7\u6b64\u4efd\u6b8a\u8363\uff1f \u201c\u6211\u5e0c\u671b\u5229\u7528\u8ba1\u7b97\u751f\u7269\u5b66\u65b9\u6cd5\u52a0\u6df1\u6211\u4eec\u5bf9\u4f53\u6db2\u514d\u75ab\u7684\u7406\u89e3\uff0c\u4ece\u800c\u4e3a\u75ab\u82d7\u7814\u53d1\u63d0\u4f9b\u65b0\u7684\u601d\u8def\uff0c\u4e3a\u514d\u75ab\u76f8\u5173\u75be\u75c5\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u9776\u70b9\u3002\u201d \u8fd9\u662f\u9648\u94bf\u96e8\u5173\u4e8e\u79d1\u7814\u8bbe\u60f3\u7684\u9648\u8ff0\uff0c\u8ba9\u4eba\u5fc3\u52a8\u3002 \u968f\u7740\u8fd1\u5e74\u6765\u6570\u636e\u83b7\u53d6\u3001\u5904\u7406\u4e0e\u4eba\u5de5\u667a\u80fd\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u8ba1\u7b97\u673a\u6280\u672f\u5728\u57fa\u7840\u79d1\u5b66\u7684\u7814\u7a76\u4e2d\u4e5f\u626e\u6f14\u7740\u6108\u53d1\u91cd\u8981\u7684\u4f5c\u7528\uff1b\u4eba\u7c7b\u793e\u4f1a\u5f53\u4e0b\u6240\u9762\u4e34\u7684\u5171\u540c\u95ee\u9898\u548c\u5de8\u5927\u6311\u6218\uff0c\u4e5f\u8feb\u5207\u5730\u9700\u8981\u57fa\u7840\u79d1\u5b66\u7814\u7a76\u4e0e\u8ba1\u7b97\u673a\u5b66\u79d1\u6709\u66f4\u52a0\u7d27\u5bc6\u7684\u4ea4\u53c9\u4e0e\u878d\u5408\u3002\u57fa\u4e8e\u8fd9\u4e00\u8d8b\u52bf\u548c\u9700\u6c42\uff0c\u4e3a\u66f4\u597d\u5730\u53d1\u6398\u5728\u57fa\u7840\u79d1\u5b66\u7814\u7a76\u4e2d\u901a\u8fc7\u8ba1\u7b97\u673a\u7406\u8bba\u4e0e\u6280\u672f\u521b\u65b0\u63a8\u52a8\u672c\u9886\u57df\u53d1\u5c55\u7684\u590d\u5408\u5b66\u672f\u4eba\u624d\uff0c\u652f\u6301\u548c\u9f13\u52b1\u6709\u6f5c\u529b\u7684\u5b66\u751f\u66f4\u597d\u5730\u5f00\u5c55\u4ea4\u53c9\u9886\u57df\u7814\u7a76\u5de5\u4f5c\uff0c2021 \u5e74\u201c\u5fae\u8f6f\u5b66\u8005\u201d\u5956\u5b66\u91d1\u7ee7\u7eed\u9762\u5411\u201c\u8ba1\u7b97\u79d1\u5b66\u201d\u9886\u57df\u63a5\u6536\u7533\u8bf7\u3002 \u9648\u94bf\u96e8\u4e13\u653b\u7684\u8ba1\u7b97\u751f\u7269\u5b66\uff0c\u6b63\u662f\u5c06\u8ba1\u7b97\u601d\u7ef4\u548c\u65b9\u6cd5\u5e94\u7528\u4e8e\u751f\u547d\u79d1\u5b66\u7814\u7a76\u7684\u4e00\u95e8\u5b66\u79d1\u3002\u5b83\u5c06\u6570\u636e\u5206\u6790\u3001\u6570\u5b66\u5efa\u6a21\u548c\u8ba1\u7b97\u673a\u4eff\u771f\u7b49\u5de5\u5177\u5f15\u5165\u751f\u7269\u5b66\u9886\u57df\uff0c\u91cd\u5851\u4e86\u751f\u7269\u5b66\u7814\u7a76\u7684\u65b9\u5f0f\uff0c\u5e76\u62d3\u5c55\u4e86\u751f\u7269\u5b66\u9886\u57df\u3002 \u4f53\u6db2\u514d\u75ab\uff0c\u5219\u96b6\u5c5e\u4eba\u4f53\u7684\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u4e3b\u8981\u7531 B \u7ec6\u80de\u4ecb\u5bfc\uff0c\u662f\u673a\u4f53\u62b5\u5fa1\u75c5\u539f\u5fae\u751f\u7269\u611f\u67d3\u7684\u91cd\u8981\u9632\u7ebf\u3002\u5f53 B \u7ec6\u80de\u53d7\u5230\u6297\u539f\u523a\u6fc0\u540e\uff0c\u80fd\u591f\u8fc5\u901f\u6d3b\u5316\u589e\u6b96\u5e76\u5206\u5316\u4e3a\u6d46\u7ec6\u80de\uff0c\u4ea7\u751f\u5927\u91cf\u6297\u4f53\uff0c\u7279\u5f02\u6027\u5730\u7ed3\u5408\u5e76\u6e05\u9664\u6297\u539f\u3002 \u8fd9\u4e2a\u8fc7\u7a0b\u975e\u5e38\u5feb\u901f\uff0c\u4e00\u822c\u4ec5\u8017\u65f6\u5341\u51e0\u5929\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u6211\u4eec\u8eab\u4f53\u5fae\u89c2\u5c42\u9762 B \u7ec6\u80de\u7684\u5c0f\u4e16\u754c\u91cc\uff0c\u4e5f\u53d1\u751f\u7740\u5982\u540c\u8fbe\u5c14\u6587\u8fdb\u5316\u8bba\u4e00\u822c\u7684\u201c\u6f14\u53d8\u201d\u3002B \u7ec6\u80de\u7684\u8fd9\u4e2a\u201c\u5fae\u578b\u8fdb\u5316\u7cfb\u7edf\u201d\uff0c\u6b63\u662f\u9648\u94bf\u96e8\u6240\u5728\u5b9e\u9a8c\u5ba4\u91cd\u70b9\u653b\u5173\u7684\u65b9\u5411\u4e4b\u4e00\u3002\u4ed6\u4eec\u60f3\u8981\u641e\u61c2\u5176\u4e2d\u7684\u673a\u7406\u2014\u2014\u662f\u4ec0\u4e48\u80de\u5185\u5206\u5b50\u4fe1\u53f7\u5728\u9a71\u52a8 B \u7ec6\u80de\u7684\u6b63\u5411\u7b5b\u9009\uff1f \u90a3\u8ba1\u7b97\u673a\u79d1\u5b66\u4e3a\u4f55\u4e0e\u4e4b\u76f8\u5173\uff1f\u9648\u94bf\u96e8\u89e3\u91ca\uff1a\u201c\u5728\u8fd9\u6837\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u80fd\u591f\u4ece\u5927\u91cf\u7684\u3001\u9ad8\u590d\u6742\u5ea6\u7684\u5b9e\u9a8c\u6570\u636e\u4e2d\u6316\u6398\u51fa\u9690\u85cf\u7684\u6a21\u5f0f\uff0c\u5f62\u6210\u5047\u8bbe\uff0c\u4e3a\u8fdb\u4e00\u6b65\u7684\u5b9e\u9a8c\u9a8c\u8bc1\u63d0\u4f9b\u6307\u5bfc\u3002\u201d \u7b80\u5355\u7406\u89e3\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u80fd\u591f\u66f4\u597d\u5730\u5e2e\u6211\u4eec\u8fdb\u884c\u751f\u7269\u76f8\u5173\u7684\u6570\u636e\u5904\u7406\u4e0e\u7b5b\u9009\uff0c\u5c31\u50cf\u4e00\u4e2a\u201c\u653e\u5927\u955c\u201d\uff0c\u8ba9\u6211\u4eec\u5728\u7ec6\u679d\u672b\u8282\u4e0a\u770b\u6e05\u695a B \u7ec6\u80de\u514d\u75ab\u6f14\u5316\u7684\u8fc7\u7a0b\u3002 \u9648\u94bf\u96e8\u5728\u672c\u6b21\u5fae\u8f6f\u5956\u5b66\u91d1\u7533\u8bf7\u4e2d\u63d0\u4ea4\u7684\u65b9\u5411\uff0c\u5e76\u975e\u201c\u7eb8\u4e0a\u8c08\u5175\u201d\u3002 2021 \u5e74 5 \u6708\uff0c\u5728\u5f00\u59cb\u535a\u58eb\u9636\u6bb5\u5b66\u4e60 9 \u4e2a\u6708\u540e\uff0c\u4ed6\u4f5c\u4e3a\u5171\u540c\u4e00\u4f5c\u7f72\u540d\u7684\u7814\u7a76\u6587\u7ae0\u201cCoupled analysis of transcriptome and BCR mutations reveals role [&hellip;]<\/p>\n","protected":false},"author":34512,"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-content-parent":1059252,"msr_hide_image_in_river":0,"footnotes":""},"research-area":[],"msr-locale":[268881],"msr-post-option":[],"class_list":["post-1074438","msr-blog-post","type-msr-blog-post","status-publish","hentry","msr-locale-zh_cn"],"msr_assoc_parent":{"id":1059252,"type":"academic-program"},"_links":{"self":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-blog-post\/1074438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-blog-post"}],"about":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/types\/msr-blog-post"}],"author":[{"embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/users\/34512"}],"version-history":[{"count":4,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-blog-post\/1074438\/revisions"}],"predecessor-version":[{"id":1080018,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-blog-post\/1074438\/revisions\/1080018"}],"wp:attachment":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/media?parent=1074438"}],"wp:term":[{"taxonomy":"msr-research-area","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/research-area?post=1074438"},{"taxonomy":"msr-locale","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-locale?post=1074438"},{"taxonomy":"msr-post-option","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-post-option?post=1074438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}