{"id":1147840,"date":"2025-08-13T03:28:37","date_gmt":"2025-08-13T10:28:37","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-blog-post&p=1147840"},"modified":"2025-08-13T03:28:51","modified_gmt":"2025-08-13T10:28:51","slug":"causcell","status":"publish","type":"msr-blog-post","link":"https:\/\/www.microsoft.com\/en-us\/research\/articles\/causcell\/","title":{"rendered":"CausCell\uff1a\u865a\u62df\u7ec6\u80de\u8fdb\u5165\u201c\u767d\u76d2\u65f6\u4ee3\u201d"},"content":{"rendered":"\n

\u7f16\u8005\u6309\uff1a\u5728\u751f\u547d\u79d1\u5b66\u7814\u7a76\u4e2d\uff0c\u903c\u771f\u4e14\u53ef\u89e3\u91ca\u7684\u7ec6\u80de\u6a21\u578b\u4e00\u76f4\u5907\u53d7\u671f\u5f85\u3002\u4f46\u73b0\u6709\u7684\u5355\u7ec6\u80de AI \u5efa\u6a21\u591a\u4f9d\u8d56\u4e8e\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u7b49\u201c\u9ed1\u76d2\u201d\u65b9\u6cd5\uff0c\u96be\u4ee5\u89e3\u5f00\u9ad8\u7ef4\u7ec4\u5b66\u6570\u636e\u80cc\u540e\u7684\u751f\u7269\u5b66\u56e0\u679c\u673a\u5236\u3002\u8fd1\u65e5\uff0c\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\uff08\u4e0a\u6d77\uff09\u4e0e\u540c\u6d4e\u5927\u5b66\u5408\u4f5c\u5728 \u300a\u81ea\u7136-\u901a\u8baf\u300b\uff08Nature Communications\uff09\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u6700\u65b0\u6210\u679c CausCell\u3002\u8fd9\u4e00\u6846\u67b6\u9996\u6b21\u5c06\u7ed3\u6784\u56e0\u679c\u6a21\u578b\u4e0e\u6269\u6563\u6a21\u578b\u6df1\u5ea6\u878d\u5408\uff0c\u5b9e\u73b0\u4e86\u7ec6\u80de\u5c3a\u5ea6\u7684\u56e0\u679c\u89e3\u8026\u8868\u5f81\u4e0e\u53ef\u63a7\u7684\u53cd\u4e8b\u5b9e\u751f\u6210\uff0c\u4e3a\u865a\u62df\u7ec6\u80de\u6784\u5efa\u63d0\u4f9b\u4e86\u53ef\u89e3\u91ca\u3001\u53ef\u6cdb\u5316\u7684\u201c\u767d\u76d2\u201d\u65b0\u8def\u5f84\u3002CausCell \u4e0d\u4ec5\u5728\u591a\u9879\u6307\u6807\u4e0a\u8d85\u8d8a\u73b0\u6709\u65b9\u6cd5\uff0c\u8fd8\u5728\u5c0f\u6837\u672c\u60c5\u5883\u4e2d\u63ed\u793a\u4e86\u8870\u8001\u76f8\u5173\u57fa\u56e0\u7684\u751f\u7269\u5b66\u65b0\u53d1\u73b0\uff0c\u4e3a\u751f\u547d\u79d1\u5b66\u6570\u5b57\u5316\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002<\/p>\n\n\n\n

\u672c\u6587\u8f6c\u8f7d\u81ea\u516c\u4f17\u53f7 \u201cBioArt\u201d\uff0c\u539f\u6587\u6807\u9898\u300a\u4e13\u5bb6\u70b9\u8bc4Nat Commun\u4e28\u5218\u7426\u56e2\u961f\u7b49\u53d1\u5e03\u865a\u62df\u7ec6\u80de\u6784\u5efa\u7684AI\u201c\u767d\u76d2\u201d\u6846\u67b6CausCell\uff0c\u63a2\u7d22\u865a\u62df\u7ec6\u80de\u6784\u5efaAI\u521b\u65b0\u8303\u5f0f\u300b\u3002<\/p>\n\n\n\n

\n\n\n\n

\u5728\u751f\u547d\u79d1\u5b66\u7684\u6570\u5b57\u5316\u8fdb\u7a0b\u4e2d\uff0c\u6784\u5efa\u9ad8\u4fdd\u771f\u865a\u62df\u7ec6\u80de\uff08virtual cell\uff09\u88ab\u89c6\u4e3a\u201c\u6570\u5b57\u751f\u7269\u5b66\u201d\u9886\u57df\u7684\u5723\u676f\u3002\u5176\u4e2d\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u4f5c\u4e3a\u89e3\u6790\u5355\u7ec6\u80de\u5c3a\u5ea6\u751f\u7269\u5b66\u529f\u80fd\u7684\u4e00\u79cd\u5173\u952e\u6280\u672f\u624b\u6bb5\uff0c\u6b63\u6df1\u523b\u91cd\u5851\u73b0\u4ee3\u751f\u7269\u5b66\u7814\u7a76\u7684\u683c\u5c40\u3002\u5982\u4f55\u57fa\u4e8e\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u5bf9\u4e8e\u7ec6\u80de\u8fdb\u884c\u6709\u6548\u8868\u5f81\uff0c\u662f\u865a\u62df\u7ec6\u80de AI \u6784\u5efa\u7684\u6838\u5fc3\u95ee\u9898\u3002<\/p>\n\n\n\n

\u9886\u57df\u5185\u76ee\u524d\u5927\u91cf\u7684\u5de5\u4f5c\u5747\u540c\u8d28\u5316\u805a\u7126\u4e8e\u53d1\u5c55\u4ee5\u4f20\u7edf\u751f\u6210\u5f0f AI\uff08\u5982 VAE\u3001AutoEncoder-based\uff09\u548c\u5355\u7ec6\u80de\u5927\u6a21\u578b\uff08foundation model\uff09\u4e3a\u4e3b\u5bfc\u7684\u8868\u5f81\u65b9\u6cd5\uff0c\u4f46\u8be5\u7c7b\u6a21\u578b\u672c\u8d28\u4e0a\u57fa\u4e8e\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u548c\u81ea\u7f16\u7801\u5668\u7b49\u201c\u9ed1\u7bb1\u201d\u8868\u5f81\uff0c\u867d\u80fd\u4ece\u7ec4\u5b66\u4e2d\u63d0\u53d6\u9690\u542b\u7279\u5f81\uff0c\u4f46\u65e0\u6cd5\u5bf9\u7ec6\u80de\u76f8\u4e92\u8026\u5408\u7684\u6f5c\u5728\u56e0\u7d20\uff08\u5982\u7ec6\u80de\u7c7b\u578b\u3001\u7ec6\u80de\u72b6\u6001\u3001\u5185\u9a71\u6807\u5fd7\u7269\uff0c\u5916\u5728\u73af\u5883\u523a\u6fc0\u54cd\u5e94\uff09\u8fdb\u884c\u7406\u89e3\u548c\u8bc6\u522b\u3002\u9762\u5bf9\u9ad8\u7ef4\u5ea6\u3001\u9ad8\u566a\u58f0\u3001\u751f\u7269\u5b66\u6982\u5ff5\uff08Biological Concept\uff09\u9ad8\u5ea6\u7ea0\u7f20\uff08Entanglement\uff09\u7684\u5355\u7ec6\u80de\u7ec4\u5b66\u201c\u6208\u8033\u72c4\u4e4b\u7ed3\u201d\uff08\u6ce8\uff1a\u6e90\u4e8e\u4f5b\u5f8b\u57fa\u4e9a\u4f20\u8bf4\uff0c\u8bb0\u8f7d\u4e8e\u5b99\u65af\u795e\u5e99\u4e2d\u7684\u725b\u8f66\u7ef3\u7ed3\uff0c\u662f’\u7f20\u7ed5\u4e0d\u5df2\u3001\u96be\u4ee5\u7406\u6e05\u7684\u95ee\u9898’\u7684\u7ecf\u5178\u9690\u55bb\uff09\uff0c\u8be5\u7c7b\u8868\u5f81\u65b9\u6cd5\u7f3a\u4e4f\u5bf9\u6f5c\u5728\u7ec6\u80de\u751f\u7269\u5b66\u673a\u5236\u7684\u53ef\u89e3\u91ca\u6027\u548c\u76f8\u5173\u751f\u7269\u5b66\u56e0\u5b50\u7684\u53ef\u64cd\u63a7\u6027\u3002\u5c24\u5176\u5728\u5efa\u6a21\u7ec6\u80de\u53d1\u80b2\u8f68\u8ff9\u3001\u75be\u75c5\u6f14\u5316\u6216\u7a7a\u95f4-\u65f6\u95f4\u53d8\u5316\u7b49\u590d\u6742\u573a\u666f\u65f6\uff0c\u6a21\u578b\u82e5\u65e0\u6cd5\u8bc6\u522b\u548c\u89e3\u8026\u6f5c\u5728\u751f\u7269\u5b66\u6982\u5ff5\uff08\u5982\u611f\u67d3\u72b6\u6001\u3001\u65f6\u95f4\u3001\u5904\u7406\u65b9\u5f0f\u7b49\uff09\uff0c\u5c06\u4e25\u91cd\u9650\u5236\u5176\u6a21\u578b\u540e\u7eed\u7684\u63a8\u7406\u80fd\u529b\u3002<\/p>\n\n\n\n

\u8fd1\u65e5\uff0c\u540c\u6d4e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u4e0e\u6280\u672f\u5b66\u9662\u751f\u7269\u4fe1\u606f\u7cfb\u3001\u540c\u6d4e\u5927\u5b66-\u4e0a\u6d77\u81ea\u4e3b\u667a\u80fd\u65e0\u4eba\u7cfb\u7edf\u79d1\u5b66\u4e2d\u5fc3\u5218\u7426\u6559\u6388\u8bfe\u9898\u7ec4\u8054\u5408\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\uff08\u4e0a\u6d77\uff09\u674e\u4e1c\u80dc\u56e2\u961f\u5728\u00a0\u300a\u81ea\u7136-\u901a\u8baf\u300b\uff08Nature Communications\uff09\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u00a0<\/strong>Causal disentanglement for single-cell representations and controllable counterfactual generation (opens in new tab)<\/span><\/a> \u7684\u7814\u7a76\u8bba\u6587\u3002\u8be5\u4ea4\u53c9\u56e2\u961f\u9996\u6b21\u53d1\u5e03\u57fa\u4e8e\u56e0\u679c\u89e3\u8026\uff08Causal Disentanglement\uff09\u7684\u865a\u62df\u7ec6\u80de\u6784\u5efa AI \u6846\u67b6 CausCell\u3002<\/p>\n\n\n\n

\u5408\u4f5c\u56e2\u961f\u8ba4\u4e3a\uff0c\u4ee5\u5355\u7ec6\u80de\u5927\u6a21\u578b\u7b49\u4e3a\u4e3b\u5bfc\u7684\u201c\u9ed1\u76d2\u201d\u8868\u5f81\u65b9\u5f0f\uff0c\u53ef\u80fd\u5e76\u975e\u662f\u865a\u62df\u7ec6\u80de AI \u6784\u5efa\u7684\u4e00\u79cd\u6709\u6548\u65b9\u5f0f\uff0c\u9886\u57df\u5185\u4e9f\u5f85\u63a2\u7d22\u865a\u62df\u7ec6\u80de AI \u6784\u5efa\u7684\u521b\u65b0\u8303\u5f0f\u3002<\/p>\n\n\n\n

CausCell \u9996\u6b21\u5c06\u7ed3\u6784\u56e0\u679c\u6a21\u578b\uff08SCM\uff09\u4e0e\u6269\u6563\u6a21\u578b\u6df1\u5ea6\u878d\u5408\uff0c\u63d0\u51fa\u4e00\u79cd\u5b9e\u73b0\u7ec6\u80de\u5c3a\u5ea6\u56e0\u679c\u89e3\u8026\u8868\u5f81\u4e0e\u53cd\u4e8b\u5b9e\u751f\u6210\u7684\u865a\u62df\u7ec6\u80de AI \u6784\u5efa\u521b\u65b0\u8def\u5f84\u3002<\/strong>\u8fd9\u4e00\u8def\u5f84\u7a81\u7834\u4f20\u7edf\u5355\u7ec6\u80de\u201c\u9ed1\u76d2\u201d\u8868\u5f81\u74f6\u9888\uff0c\u4e0d\u4ec5\u4e3a\u865a\u62df\u7ec6\u80de AI \u6784\u5efa\u63d0\u4f9b\u4e86\u53ef\u89e3\u91ca\u3001\u53ef\u6cdb\u5316\u7684\u201c\u767d\u76d2\u201d\u8868\u5f81\u65b0\u8303\u5f0f\uff0c\u66f4\u5728\u5c0f\u6837\u672c\u7ec4\u5b66\u6837\u672c\u573a\u666f\u4e0b\u6210\u529f\u8bc6\u522b\u51fa\u8870\u8001\u76f8\u5173\u57fa\u56e0\uff0c\u4e3a\u865a\u62df\u7ec6\u80de AI \u6784\u5efa\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u522b\u4e8e\u5355\u7ec6\u80de\u57fa\u7840\u6a21\u578b\u201c\u9ed1\u76d2\u201d\u8868\u5f81\u7684\u521b\u65b0\u8def\u5f84\u3002<\/strong><\/p>\n\n\n\n

\"graphical<\/figure>\n\n\n\n

\u5728\u8be5\u865a\u62df\u7ec6\u80de\u5efa\u6a21\u8bbe\u8ba1\u4e0a\uff0cCausCell \u5c06\u5355\u7ec6\u80de\u7ec4\u5b66\u8868\u5f81\u5206\u89e3\u4e3a\u53ef\u89c2\u6d4b\u6982\u5ff5<\/strong>\uff08\u5982\u7ec6\u80de\u7c7b\u578b\u3001\u7ec4\u7ec7\u6765\u6e90\uff09\u4e0e\u672a\u89e3\u91ca\u6982\u5ff5<\/strong>\uff08\u566a\u58f0\u3001\u672a\u77e5\u751f\u7269\u53d8\u5f02\uff09\uff0c\u8be5\u673a\u5236\u4f7f\u5f97\u6a21\u578b\u4e0d\u4ec5\u53ef\u4ee5\u6709\u6548\u89e3\u8026\u590d\u6742\u751f\u7269\u6982\u5ff5\uff0c\u8fd8\u53ef\u5bf9\u6bcf\u4e2a\u7ec6\u80de\u8fdb\u884c\u4e2a\u6027\u5316\u63a7\u5236\u4e0e\u751f\u6210\u3002<\/p>\n\n\n\n

\u5177\u4f53\u800c\u8a00\uff0cCausCell \u901a\u8fc7\u4e24\u5927\u6a21\u5757\u5b9e\u73b0\u56e0\u679c\u89e3\u8026\u8868\u5f81\uff1a<\/p>\n\n\n\n

\uff081\uff09\u56e0\u679c\u89e3\u8026\u6a21\u5757\uff1a\u91c7\u7528 SCM \u5c42\u5efa\u6a21\u6982\u5ff5\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u751f\u6210\u5177\u6709\u751f\u7269\u8bed\u4e49\u7684\u5185\u751f\u5d4c\u5165\uff1b<\/p>\n\n\n\n

\uff082\uff09\u6269\u6563\u751f\u6210\u6a21\u5757\uff1a\u57fa\u4e8e\u8de8\u6ce8\u610f\u529b\u673a\u5236\u7684\u5bf9\u89e3\u8026\u7684\u5f52\u7eb3\u504f\u7f6e\u4f18\u52bf\uff0c\u540c\u65f6\u901a\u8fc7\u56e0\u679c\u5d4c\u5165\u5f15\u5bfc\u6269\u6563\u751f\u6210\u8fc7\u7a0b\uff0c\u4ece\u800c\u751f\u6210\u7b26\u5408\u771f\u5b9e\u751f\u7269\u89c4\u5f8b\u7684\u6837\u672c\uff08\u5982\u56fe1\u6240\u793a\uff09\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0c\u4e3a\u63d0\u5347\u6a21\u578b\u8bad\u7ec3\u6548\u7387\u4e0e\u89e3\u8026\u6548\u679c\uff0c\u7814\u7a76\u56e2\u961f\u8bbe\u8ba1\u4e86\u65b0\u7684\u635f\u5931\u51fd\u6570\uff0c\u7efc\u5408\u5f15\u5165\u8bc1\u636e\u4e0b\u754c\uff08ELBO\uff09\u635f\u5931\u9879\u4e0e\u4e0d\u53ef\u89e3\u91ca\u6982\u5ff5\u72ec\u7acb\u6027\u7ea6\u675f<\/strong>\uff0c\u786e\u4fdd\u6f5c\u53d8\u91cf\u95f4\u7684\u6e05\u6670\u8fb9\u754c\u4e0e\u8868\u8fbe\u7cbe\u5ea6\u3002<\/p>\n\n\n\n

\u603b\u4f53\u800c\u8a00\uff0cCausCell \u6240\u63d0\u4f9b\u7684\u865a\u62df\u7ec6\u80de\u6784\u5efa\u6846\u67b6\u5177\u5907\u4e09\u5927\u6838\u5fc3\u4f18\u52bf\uff1a<\/p>\n\n\n\n

\uff081\uff09\u53ef\u89e3\u91ca\u6027\uff08Explainability\uff09<\/strong>\uff1a\u6a21\u578b\u501f\u52a9\u56e0\u679c\u6709\u5411\u65e0\u73af\u56fe\uff08cDAG\uff09\uff0c\u4ece\u6f5c\u5728\u7a7a\u95f4\u4e2d\u6062\u590d\u5177\u5907\u8bed\u4e49\u610f\u4e49\u7684\u751f\u7269\u5b66\u6982\u5ff5\u53ca\u5176\u56e0\u679c\u5173\u7cfb\uff0c\u5927\u5e45\u589e\u5f3a\u4e86\u6a21\u578b\u5bf9\u751f\u7269\u673a\u5236\u7684\u89e3\u91ca\u80fd\u529b\uff1b<\/p>\n\n\n\n

\uff082\uff09\u6cdb\u5316\u6027\uff08Generalizability\uff09<\/strong>\uff1a\u4e0d\u540c\u4e8e\u4ee5\u5f80\u57fa\u4e8e VAE \u7684\u751f\u6210\u65b9\u6cd5\uff0cCausCell \u4ee5\u6269\u6563\u6a21\u578b\u4f5c\u4e3a\u751f\u6210\u4e3b\u5e72\uff0c\u5177\u5907\u5f3a\u5927\u7684\u6570\u636e\u8868\u8fbe\u4e0e\u6cdb\u5316\u80fd\u529b\uff0c\u80fd\u591f\u5b9e\u73b0\u9ad8\u8d28\u91cf\u3001\u7a33\u5b9a\u7684\u5355\u7ec6\u80de\u7ec4\u5b66\u6837\u672c\u751f\u6210\uff1b<\/p>\n\n\n\n

\uff083\uff09\u53ef\u63a7\u6027\uff08Controllability\uff09<\/strong>\uff1a\u6a21\u578b\u53ef\u5728\u4fdd\u6301\u56e0\u679c\u4e00\u81f4\u6027\u7684\u524d\u63d0\u4e0b\uff0c\u5bf9\u6f5c\u5728\u6982\u5ff5\u7a7a\u95f4\u8fdb\u884c\u6709\u9488\u5bf9\u6027\u7684\u5e72\u9884\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u7ec6\u80de\u72b6\u6001\u7684\u53cd\u4e8b\u5b9e\u6a21\u62df\u751f\u6210\u3002<\/p>\n\n\n\n

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\"diagram,
\u56fe1\uff1aCausCell \u6846\u67b6\u56fe<\/figcaption><\/figure>\n\n\n\n

\u4e3a\u5168\u9762\u8bc4\u4f30 CausCell \u7684\u89e3\u8026\u6027\u80fd\uff0c\u7814\u7a76\u56e2\u961f\u540c\u65f6\u6784\u5efa\u4e86\u9886\u57df\u5185\u9996\u4e2a\u7cfb\u7edf\u6027\u7684\u865a\u62df\u7ec6\u80de\u89e3\u8026\u8868\u5f81\u7684\u57fa\u51c6\u4f53\u7cfb<\/strong>\u3002\u9009\u53d6\u4e94\u4e2a\u771f\u5b9e\u751f\u7269\u6570\u636e\u96c6\u6db5\u76d6\u4e0d\u540c\u7269\u79cd\u3001\u7ec4\u7ec7\u548c\u6280\u672f\u5e73\u53f0\uff0c\u5e76\u5728\u201c\u5206\u5e03\u5185\uff08ID\uff09\u201d\u4e0e\u201c\u5206\u5e03\u5916\uff08OOD\uff09\u201d\u4e24\u7c7b\u573a\u666f\u4e2d\u8fdb\u884c\u5176\u8868\u5f81\u6027\u80fd\u6d4b\u8bd5\u3002<\/p>\n\n\n\n

\u7ed3\u679c\u663e\u793a\uff1a\u5728\u89e3\u8026\u6982\u5ff5\u7684\u9884\u6d4b\u51c6\u786e\u7387\u3001\u805a\u7c7b\u4e00\u81f4\u6027\u3001\u6297\u6279\u6b21\u6548\u5e94\u80fd\u529b\u7b49\u591a\u4e2a\u7ef4\u5ea6\u4e0a\uff0cCausCell \u5747\u663e\u8457\u4f18\u4e8e\u76f8\u5173\u5177\u5907\u4e00\u5b9a\u89e3\u8026\u80fd\u529b\u7684\u8ba1\u7b97\u6a21\u578b\uff08\u5982 scDisInFact\u3001Biolord\u3001CPA \u7b49\uff09\uff1b\u5728\u751f\u6210\u8d28\u91cf\u8bc4\u4f30\u4e2d\uff0cCausCell \u5728\u8d8b\u52bf\u5339\u914d\u3001\u7ed3\u6784\u4fdd\u6301\u53ca\u6807\u5fd7\u57fa\u56e0\u4fdd\u771f\u5ea6\u7b49\u65b9\u9762\u4e0d\u4ec5\u4f18\u4e8e\u524d\u8ff0\u6a21\u578b\uff0c\u4e5f\u6301\u5e73\u751a\u81f3\u8d85\u8fc7\u4e3b\u6d41\u7684\u751f\u6210\u5f0f\u6a21\u578b\uff08\u5982 scVI\u3001scGen\uff09\uff08\u5982\u56fe2\u6240\u793a\uff09\uff1b\u66f4\u91cd\u8981\u7684\u662f\uff0cCausCell \u9996\u6b21\u63d0\u4f9b\u4e00\u79cd\u51c6\u786e\u6a21\u62df\u56e0\u679c\u5e72\u9884\u6548\u5e94\u7684\u7ec6\u80de\u865a\u62df\u751f\u6210\u8def\u5f84\uff0c\u800c\u7ec6\u80de\u865a\u62df\u751f\u6210\u662f\u865a\u62df\u7ec6\u80de\u6784\u5efa\u7684\u91cd\u8981\u5e94\u7528\u9700\u6c42<\/strong>\u3002\u901a\u8fc7\u5728\u759f\u539f\u866b\u611f\u67d3\u7684\u65f6\u7a7a\u809d\u810f\u6570\u636e\u96c6\u4e0a\u6240\u8fdb\u884c\u7684\u865a\u62df\u5e72\u9884\u5b9e\u9a8c\u8868\u660e\uff1a\u7f3a\u4e4f\u56e0\u679c\u7ed3\u6784\u7ea6\u675f\u7684\u6a21\u578b\u6240\u751f\u6210\u7684\u865a\u62df\u7ec6\u80de\u9519\u8bef\u5730\u663e\u793a\u9ad8\u611f\u67d3\u8bc4\u5206\uff0c\u800c\u8003\u8651\u56e0\u679c\u7ed3\u6784\u7ea6\u675f\u7684\u6a21\u578b\u5219\u51c6\u786e\u53cd\u6620”\u65f6\u95f4\u2192\u611f\u67d3\u2192\u8868\u578b”\u7684\u56e0\u679c\u94fe\u3002\u7531\u6b64\u53ef\u89c1\uff1a\u4f20\u7edf\u4e0d\u5177\u5907\u56e0\u679c\u5efa\u6a21\u80fd\u529b\u7684\u6a21\u578b\u751f\u6210\u7684\u865a\u62df\u7ec6\u80de\u5728\u751f\u7269\u6307\u6807\u4e0a\u8868\u73b0\u51fa\u4e0d\u7b26\u5408\u751f\u7269\u5b66\u673a\u5236\u7ea6\u675f\u7684\u5931\u771f\u884c\u4e3a\uff0c\u800c\u56e0\u679c\u4e00\u81f4\u6027\u4f7f\u53cd\u4e8b\u5b9e\u751f\u6210\u66f4\u7b26\u5408\u751f\u7269\u5b66\u903b\u8f91\u3002<\/p>\n\n\n\n

\u540c\u65f6\uff0c\u5728\u771f\u5b9e\u5e94\u7528\u573a\u666f\u4e2d\uff0c\u5355\u7ec6\u80de\u7ec4\u5b66\u6837\u672c\u5f80\u5f80\u6837\u672c\u91cf\u6709\u9650\u3001\u6210\u672c\u9ad8\u6602\uff0cCausCell \u5177\u5907\u7684\u53cd\u4e8b\u5b9e\u751f\u6210\u80fd\u529b\u5728\u6b64\u60c5\u5f62\u4e0b\u5c55\u73b0\u51fa\u6f5c\u529b\uff1a\u5728\u5206\u6790\u4ec5\u542b2\u53ea\u5c0f\u9f20\/\u5e74\u9f84\u7ec4\u7684\u8111\u8870\u8001 MERFISH \u6570\u636e\u65f6\uff0c\u901a\u8fc7\u5e74\u9f84\u6982\u5ff5\u5e72\u9884\u6210\u529f\u6a21\u62df\u4e0d\u540c\u5e74\u9f84\u6bb5\u7ec6\u80de\u7684\u8f6c\u5f55\u53d8\u5316\u8d8b\u52bf\uff0c\u590d\u73b0\u5df2\u6709\u7ed3\u8bba\uff0c\u5e76\u8fdb\u4e00\u6b65 de novo \u8bc6\u522b\u51fa\u4e0e\u8870\u8001\u76f8\u5173\u7684\u514d\u75ab\u8c03\u8282\u57fa\u56e0\u5728\u7eb9\u72b6\u4f53\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e2d\u7279\u5f02\u6027\u4e0a\u8c03\uff0c\u5176\u5bcc\u96c6\u7684T\u7ec6\u80de\u6fc0\u6d3b\u901a\u8def\u63d0\u793a\u8be5\u533a\u57df\u5b58\u5728\u72ec\u7279\u7684\u514d\u75ab\u91cd\u5851\u673a\u5236\uff0c\u4e3a\u7406\u89e3\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u63d0\u4f9b\u4e86\u5d2d\u65b0\u89c6\u89d2\u3002<\/p>\n\n\n\n

\"chart,
\u56fe2\uff1aCausCell \u6027\u80fd\u6d4b\u8bc4<\/figcaption><\/figure>\n\n\n\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u672c\u6b21\u7531\u4ea4\u53c9\u56e2\u961f\u8054\u5408\u53d1\u5e03\u7684\u00a0CausCell \u4f5c\u4e3a\u9886\u57df\u5185\u9996\u4e2a\u878d\u5408\u7ed3\u6784\u56e0\u679c\u5efa\u6a21\u4e0e\u6269\u6563\u751f\u6210\u673a\u5236\u7684\u865a\u62df\u7ec6\u80de\u5efa\u6a21\u7684 AI \u201c\u767d\u76d2\u201d\u6846\u67b6\uff0c\u4e0d\u4ec5\u5728\u865a\u62df\u7ec6\u80de\u7684\u89e3\u8026\u8868\u5f81\u3001\u53cd\u4e8b\u5b9e\u751f\u6210\u7b49\u5173\u952e\u4efb\u52a1\u4e0a\u5b9e\u73b0\u4e86\u65b9\u6cd5\u8def\u5f84\u7684\u91cd\u8981\u7a81\u7834\uff0c\u66f4\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\u5c55\u73b0\u51fa\u53ef\u4fe1\u7684\u751f\u7269\u5b66\u6d1e\u5bdf\u80fd\u529b\u4e0e\u6cdb\u5316\u80fd\u529b<\/strong>\u3002\u5176\u56e0\u679c\u9a71\u52a8\u7684\u6f5c\u53d8\u91cf\u5efa\u6a21\u65b9\u5f0f\u4f7f\u5f97\u590d\u6742\u751f\u7269\u6982\u5ff5\u5f97\u4ee5\u88ab\u6e05\u6670\u5206\u89e3\u4e0e\u64cd\u63a7\uff0c\u663e\u8457\u63d0\u5347\u4e86\u6a21\u578b\u7684\u53ef\u89e3\u91ca\u6027\u4e0e\u53ef\u63a7\u6027\uff1b\u540c\u65f6\uff0c\u6269\u6563\u751f\u6210\u6a21\u578b\u786e\u4fdd\u4e86\u751f\u6210\u6570\u636e\u7684\u751f\u7269\u771f\u5b9e\u5ea6\u4e0e\u8fde\u7eed\u6027\u8868\u8fbe\uff1b\u800c\u5728\u9762\u5bf9\u5f02\u8d28\u6570\u636e\u3001\u5206\u5e03\u5916\u4efb\u52a1\u53ca\u5c0f\u6837\u672c\u573a\u666f\u65f6\uff0cCausCell \u4ecd\u80fd\u4fdd\u6301\u7a33\u5b9a\u800c\u9ad8\u8d28\u91cf\u7684\u5efa\u6a21\u8868\u73b0\u3002CausCell \u63a8\u52a8\u4e86\u865a\u62df\u7ec6\u80de\u6784\u5efa\u4ece\u201c\u76f8\u5173\u6027\u5efa\u6a21\u201d\u8d70\u5411\u201c\u56e0\u679c\u6027\u5efa\u6a21\u201d\u7684\u5173\u952e\u4e00\u6b65\uff0c\u4e5f\u4e3a\u540e\u7eed\u6784\u5efa\u5177\u6709\u53ef\u89e3\u91ca\u6027\u4e0e\u751f\u6210\u80fd\u529b\u7684\u201c\u865a\u62df\u7ec6\u80de\u201d\u63d0\u4f9b\u4e86\u4e00\u79cd\u521b\u65b0\u6027\u7684\u65b9\u6cd5\u8def\u5f84<\/strong>\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\n\n

\n\u4e13\u5bb6\u70b9\u8bc4\n

\n\u9886\u57df\u5185\u5f53\u4e0b\u5bf9\u4e8e\u865a\u62df\u7ec6\u80de\u8868\u5f81\u7684\u7814\u7a76\u5927\u591a\u805a\u7126\u4e8e\u5355\u7ec6\u80de\u5927\u6a21\u578b\u9a71\u52a8\u7684\u76f8\u5173\u201c\u9ed1\u7bb1\u201d\u6a21\u578b\u5f00\u53d1\uff0c\u800c\u5218\u7426\u6559\u6388\u56e2\u961f\u4e0e\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\u8054\u5408\u5f00\u53d1\u7684 CausCell \u6846\u67b6\u53e6\u8f9f\u8e4a\u5f84\uff0c\u4ee3\u8868\u4e86\u865a\u62df\u7ec6\u80de\u6784\u5efa\u7684AI\u8def\u5f84\u4ece\u201c\u9ed1\u7bb1\u201d\u76f8\u5173\u6027\u5efa\u6a21\u5411\u201c\u767d\u76d2\u201d\u56e0\u679c\u6027\u5efa\u6a21\u7684\u4e00\u79cd\u53ef\u80fd\u7684\u8303\u5f0f\u8f6c\u53d8\uff0c\u540c\u65f6\u4e5f\u4e3a\u7406\u89e3\u7ec6\u80de\u72b6\u6001\u8c03\u63a7\u7684\u5e95\u5c42\u903b\u8f91\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u89e3\u91ca\u3001\u53ef\u64cd\u63a7\u7684\u65b0\u65b9\u6cd5\u3002\u8fd9\u4e00\u7814\u7a76\u7684\u91cd\u8981\u610f\u4e49\u53ef\u4ee5\u4f53\u73b0\u5728\u4e09\u4e2a\u65b9\u9762\uff1a\n

\n1. \u56e0\u679c\u89e3\u8026\u7684\u7406\u8bba\u7a81\u7834\uff1a\u4f20\u7edf\u5355\u7ec6\u80de\u8868\u5f81\u6a21\u578b\uff08\u5982 VAE\u3001\u57fa\u7840\u6a21\u578b\u7b49\uff09\u53d7\u9650\u4e8e\u751f\u7269\u6982\u5ff5\u7684\u7ea0\u7f20\u6027\uff0c\u96be\u4ee5\u89e3\u6790\u7ec6\u80de\u72b6\u6001\u7684\u5185\u751f\u9a71\u52a8\u56e0\u7d20\u3002CausCell \u901a\u8fc7\u7ed3\u6784\u56e0\u679c\u6a21\u578b\uff08SCM\uff09\u663e\u5f0f\u5efa\u6a21\u7ec6\u80de\u7c7b\u578b\u3001\u73af\u5883\u54cd\u5e94\u7b49\u6982\u5ff5\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u5355\u7ec6\u80de\u6570\u636e\u7684\u201c\u673a\u5236\u53ef\u8bfb\u201d\u8868\u5f81,\u8fd9\u79cd\u89e3\u8026\u8868\u5f81\u5b66\u4e60\u7684\u80fd\u529b\u4e3a\u75be\u75c5\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u79cd\u201c\u53ef\u89e3\u91ca\u5b66\u4e60\u201d\u7684\u65b0\u89c6\u89d2\u3002\n

\n2. \u89e3\u8026\u4e0e\u751f\u6210\u7684\u7406\u8bba\u878d\u5408\uff1a\u7814\u7a76\u56e2\u961f\u521b\u65b0\u6027\u5730\u7ed3\u5408\u56e0\u679c\u56fe\u7684\u7ed3\u6784\u7ea6\u675f\u548c\u6269\u6563\u6a21\u578b\u7684\u751f\u6210\u4f18\u52bf\uff0c\u5c1d\u8bd5\u53bb\u89e3\u51b3\u751f\u7269\u6837\u672c\u751f\u6210\u8d28\u91cf\u4e0e\u751f\u7269\u5b66\u5408\u7406\u6027\u96be\u4ee5\u517c\u987e\u7684\u91cd\u8981\u6311\u6218\u3002\u5176\u53cd\u4e8b\u5b9e\u751f\u6210\u6a21\u5757\u53ef\u7cbe\u51c6\u6a21\u62df\u5e72\u9884\u6548\u5e94\uff0c\u76f8\u6bd4\u4f20\u7edf\u751f\u6210\u6a21\u578b\uff08\u5982scVI\uff09\u66f4\u7b26\u5408\u751f\u7269\u5b66\u903b\u8f91\uff0c\u8fd9\u4e3a\u751f\u6210\u7b26\u5408\u751f\u7269\u5b66\u5e95\u5c42\u903b\u8f91\u7684\u865a\u62df\u7ec6\u80de\u63d0\u4f9b\u4e86\u53ef\u884c\u7684\u65b9\u6cd5\u8def\u5f84\u3002\n

\n3. \u5c0f\u6837\u672c\u573a\u666f\u4e0b\u7684\u751f\u7269\u77e5\u8bc6\u6316\u6398\uff1a\u5728\u5355\u7ec6\u80de\u6570\u636e\u7a00\u7f3a\u7684\u73b0\u5b9e\u6311\u6218\u4e0b\uff0cCausCell \u901a\u8fc7\u56e0\u679c\u5f52\u7eb3\u504f\u7f6e\u663e\u8457\u964d\u4f4e\u5bf9\u6837\u672c\u6570\u91cf\u7684\u4f9d\u8d56\u3002\u4f8b\u5982\u5728\u8111\u8870\u8001\u7814\u7a76\u4e2d\uff0c\u4ec5\u9700\u5c11\u91cf\u6837\u672c\u5373\u53ef\u590d\u73b0\u5df2\u77e5\u89c4\u5f8b\u5e76\u53d1\u73b0\u65b0\u57fa\u56e0\uff0c\u8fd9\u4e00\u7279\u6027\u5bf9\u9762\u5411\u7f55\u89c1\u75c5\u7b49\u5c0f\u6837\u672c\u573a\u666f\u4e0b\u7684\u751f\u7269\u77e5\u8bc6\u6316\u6398\u63d0\u4f9b\u4e86\u4e00\u79cd\u5207\u5b9e\u6709\u6548\u7684\u8ba1\u7b97\u6a21\u578b\u548c\u5de5\u5177\u3002\n

\n\u672a\u6765\uff0c\u6b64\u7c7b\u56e0\u679c\u6846\u67b6\u5c06\u6709\u671b\u62d3\u5c55\u81f3\u5668\u5b98\u6a21\u578b\u3001\u75be\u75c5\u7f51\u7edc\u7b49\u590d\u6742\u7cfb\u7edf\u5efa\u6a21\u4ee5\u53ca\u65f6\u7a7a\u52a8\u6001\u6316\u6398\uff08\u5982\u53d1\u80b2\u8f68\u8ff9\u91cd\u6784\uff09\u3002\u8be5\u7814\u7a76\u6240\u53d1\u5c55\u7684\u8fd9\u79cd\u521b\u65b0\u6027\u7684\u201c\u56e0\u679c+\u751f\u6210\u201d\u7684\u7814\u7a76\u8303\u5f0f\uff0c\u5c06\u8fdb\u4e00\u6b65\u63a8\u52a8\u865a\u62df\u7ec6\u80de\u6784\u5efa\u7684 AI \u6280\u672f\u9769\u65b0\uff0c\u540c\u65f6\u4e5f\u4e3a\u6570\u636e\u9a71\u52a8\u7684\u751f\u7269\u5b66\u7814\u7a76\u7a81\u7834\u201c\u9ed1\u76d2\u201d AI \u684e\u688f\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u884c\u7684\u65b0\u601d\u8def\u3002\n

\n\u2014\u2014\u9648\u6d1b\u5357\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u8bb2\u5e2d\u6559\u6388\n<\/p>\n<\/blockquote>\n\n\n\n

\n

\u4e13\u5bb6\u70b9\u8bc4\n

\n\u8fd1\u5e74\u6765\uff0c\u5355\u7ec6\u80de\u7ec4\u5b66\u6570\u636e\u7684\u7206\u70b8\u5f0f\u589e\u957f\u4e3a\u63ed\u793a\u751f\u7269\u5b66\u673a\u5236\u63d0\u4f9b\u4e86\u524d\u6240\u672a\u6709\u7684\u673a\u9047\u3002\u7136\u800c\uff0c\u4ece\u5982\u6b64\u9ad8\u7ef4\u4e14\u590d\u6742\u7684\u6570\u636e\u4e2d\u83b7\u53d6\u53ef\u89e3\u91ca\u3001\u53ef\u63a7\u7684\u7ec6\u80de\u8868\u793a,\u4ecd\u7136\u662f\u7814\u7a76\u4e2d\u7684\u96be\u70b9\u3002\u4f20\u7edf\u7684\u6df1\u5ea6\u751f\u6210\u6a21\u578b\uff08\u5982\u53d8\u5206\u81ea\u7f16\u7801\u5668\uff0cVAE\uff09\u867d\u53ef\u5904\u7406\u9ad8\u7ef4\u6570\u636e\uff0c\u4f46\u5728\u7ed3\u679c\u7684\u53ef\u89e3\u91ca\u6027\u548c\u751f\u6210\u7684\u53ef\u63a7\u6027\u65b9\u9762\u5b58\u5728\u660e\u663e\u5c40\u9650\uff0c\u5c24\u5176\u662f\u5728\u63a8\u65ad\u5916\u90e8\u6761\u4ef6\u6216\u5b9e\u9a8c\u6270\u52a8\u4e0b\u7684\u7ec6\u80de\u72b6\u6001\u65f6\uff0c\u7f3a\u4e4f\u8db3\u591f\u7684\u7075\u6d3b\u6027\u3002\n

\n\u5218\u7426\u56e2\u961f\u548c\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\u5408\u4f5c\u9488\u5bf9\u4e0a\u8ff0\u95ee\u9898\u8fdb\u884c\u4e86\u6df1\u5165\u7684\u601d\u8003\u548c\u63a2\u7d22\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u503c\u5f97\u5173\u6ce8\u7684\u65b0\u65b9\u6cd5\uff1a\u5c06\u89e3\u7f20\u5b66\u4e60\uff08disentangled learning\uff09\u4e0e\u6269\u6563\u6a21\u578b\uff08diffusion model\uff09\u76f8\u7ed3\u5408\uff0c\u5e76\u5f15\u5165\u7ed3\u6784\u56e0\u679c\u6a21\u578b\uff08structural causal model\uff09\uff0c\u9996\u6b21\u5728\u5355\u7ec6\u80de\u5efa\u6a21\u4e2d\u5b9e\u73b0\u4e86\u56e0\u679c\u7ed3\u6784\u4e0e\u6269\u6563\u8fc7\u7a0b\u7684\u878d\u5408\u3002\u8be5\u8bbe\u8ba1\u4f7f\u6a21\u578b\u5728\u63d0\u53d6\u7ec6\u80de\u5d4c\u5165\u65f6\u80fd\u591f\u6355\u6349\u7279\u5b9a\u6982\u5ff5\u7684\u7ec6\u80de\u8868\u793a\uff0c\u5e76\u80fd\u57fa\u4e8e\u6982\u5ff5\u5c42\u7ea7\u7684\u56e0\u679c\u5173\u7cfb\u7075\u6d3b\u8c03\u6574\u7ec6\u80de\u72b6\u6001\uff0c\u4ece\u800c\u5b9e\u73b0\u865a\u62df\u7ec6\u80de\u7684\u53cd\u4e8b\u5b9e\u751f\u6210\u3002\u5176\u4e3b\u8981\u8d21\u732e\u53ef\u6982\u62ec\u4e3a\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\uff1a\n

\n1. \u63d0\u5347\u4e86\u53ef\u89e3\u91ca\u6027\u4e0e\u53ef\u63a7\u6027\uff1a\u56e0\u679c\u7ed3\u6784\u7684\u5f15\u5165\u4f7f\u751f\u6210\u7684\u7ec6\u80de\u5d4c\u5165\u7a7a\u95f4\u80fd\u591f\u6e05\u6670\u5730\u533a\u5206\u6982\u5ff5\u56e0\u7d20\uff0c\u907f\u514d\u4e86\u4f20\u7edf\u53d8\u5206\u81ea\u7f16\u7801\u5668\u4e2d\u7531\u7ea0\u7f20\u6f5c\u53d8\u91cf\u5e26\u6765\u7684\u4e0d\u900f\u660e\u6027\u3002\n

\n2. \u65b0\u9896\u7684\u53cd\u4e8b\u5b9e\u751f\u6210\u80fd\u529b\uff1a\u8be5\u6a21\u578b\u80fd\u591f\u5408\u6210\u539f\u59cb\u6570\u636e\u4e2d\u4e0d\u5b58\u5728\u7684\u7ec6\u80de\u7c7b\u578b\u6216\u6761\u4ef6\u7ec4\u5408\u3002\u4f8b\u5982\uff0c\u5b83\u53ef\u4ee5\u6a21\u62df\u836f\u7269\u5bf9\u672a\u6d4b\u91cf\u7ec4\u7ec7\u7684\u4f5c\u7528\u7684\u865a\u62df\u7ec6\u80de\uff0c\u6709\u52a9\u4e8e\u9884\u6d4b\u5b9e\u9a8c\u7ed3\u679c\u5e76\u4f18\u5316\u7814\u7a76\u8bbe\u8ba1\u3002\n

\n3. \u4e3a\u5c0f\u6837\u672c\u7814\u7a76\u548c\u751f\u7269\u4fe1\u53f7\u6316\u6398\u63d0\u4f9b\u65b0\u5de5\u5177\uff1a\u53cd\u4e8b\u5b9e\u751f\u6210\u53ef\u589e\u5f3a\u7a00\u7f3a\u6570\u636e\u573a\u666f\u7684\u5efa\u6a21\u80fd\u529b\uff0c\u5e76\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u8bc6\u522b\u88ab\u566a\u58f0\u6216\u6570\u636e\u4e0d\u8db3\u6240\u63a9\u76d6\u7684\u751f\u7269\u5b66\u6a21\u5f0f\u3002\n

\n\u7efc\u5408\u6765\u770b\uff0c\u8fd9\u9879\u7814\u7a76\u4e3a\u5355\u7ec6\u80de\u72b6\u6001\u7684\u8868\u5f81\u4e0e\u751f\u6210\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u4e0d\u4ec5\u663e\u8457\u589e\u5f3a\u4e86\u751f\u6210\u6a21\u578b\u7684\u53ef\u89e3\u91ca\u6027\uff0c\u4e5f\u4e3a\u7814\u7a76\u4eba\u5458\u63a2\u7d22\u751f\u7269\u7cfb\u7edf\u54cd\u5e94\u3001\u8fdb\u884c\u6570\u636e\u589e\u5f3a\u53ca\u6307\u5bfc\u5b9e\u9a8c\u8bbe\u8ba1\u7b49\u65b9\u9762\u63d0\u4f9b\u4e86\u6709\u4ef7\u503c\u7684\u5de5\u5177\u3002\u8fd9\u9879\u9488\u5bf9\u5355\u7ec6\u80de\u8868\u5f81\u5b66\u4e60\u7684\u521b\u65b0\u63a2\u7d22\u5c55\u73b0\u51fa\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\uff0c\u503c\u5f97\u8be5\u9886\u57df\u7814\u7a76\u8005\u8fdb\u4e00\u6b65\u5173\u6ce8\u548c\u6df1\u5165\u7814\u7a76\u3002\uff09\n

\n\u2014\u2014\u590f\u94ee\uff0cAssociate Professor, OHSU School of Medicine, U.S.<\/p>\n<\/blockquote>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f16\u8005\u6309\uff1a\u5728\u751f\u547d\u79d1\u5b66\u7814\u7a76\u4e2d\uff0c\u903c\u771f\u4e14\u53ef\u89e3\u91ca\u7684\u7ec6\u80de\u6a21\u578b\u4e00\u76f4\u5907\u53d7\u671f\u5f85\u3002\u4f46\u73b0\u6709\u7684\u5355\u7ec6\u80de AI \u5efa\u6a21\u591a\u4f9d\u8d56\u4e8e\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u7b49\u201c\u9ed1\u76d2\u201d\u65b9\u6cd5\uff0c\u96be\u4ee5\u89e3\u5f00\u9ad8\u7ef4\u7ec4\u5b66\u6570\u636e\u80cc\u540e\u7684\u751f\u7269\u5b66\u56e0\u679c\u673a\u5236\u3002\u8fd1\u65e5\uff0c\u5fae\u8f6f\u4e9a\u6d32\u7814\u7a76\u9662\uff08\u4e0a\u6d77\uff09\u4e0e\u540c\u6d4e\u5927\u5b66\u5408\u4f5c\u5728 \u300a\u81ea\u7136-\u901a\u8baf\u300b\uff08Nature Communications\uff09\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u6700\u65b0\u6210\u679c CausCell\u3002\u8fd9\u4e00\u6846\u67b6\u9996\u6b21\u5c06\u7ed3\u6784\u56e0\u679c\u6a21\u578b\u4e0e\u6269\u6563\u6a21\u578b\u6df1\u5ea6\u878d\u5408\uff0c\u5b9e\u73b0\u4e86\u7ec6\u80de\u5c3a\u5ea6\u7684\u56e0\u679c\u89e3\u8026\u8868\u5f81\u4e0e\u53ef\u63a7\u7684\u53cd\u4e8b\u5b9e\u751f\u6210\uff0c\u4e3a\u865a\u62df\u7ec6\u80de\u6784\u5efa\u63d0\u4f9b\u4e86\u53ef\u89e3\u91ca\u3001\u53ef\u6cdb\u5316\u7684\u201c\u767d\u76d2\u201d\u65b0\u8def\u5f84\u3002CausCell \u4e0d\u4ec5\u5728\u591a\u9879\u6307\u6807\u4e0a\u8d85\u8d8a\u73b0\u6709\u65b9\u6cd5\uff0c\u8fd8\u5728\u5c0f\u6837\u672c\u60c5\u5883\u4e2d\u63ed\u793a\u4e86\u8870\u8001\u76f8\u5173\u57fa\u56e0\u7684\u751f\u7269\u5b66\u65b0\u53d1\u73b0\uff0c\u4e3a\u751f\u547d\u79d1\u5b66\u6570\u5b57\u5316\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002 \u672c\u6587\u8f6c\u8f7d\u81ea\u516c\u4f17\u53f7 \u201cBioArt\u201d\uff0c\u539f\u6587\u6807\u9898\u300a\u4e13\u5bb6\u70b9\u8bc4Nat 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