Motivation: The appropriate modulation of the stress response to
\nvariable environmental conditions is necessary to maintain sustained
\nviability in Saccharomyces cerevisiae. Particularly, controlling the
\nabundance of proteins that may have detrimental effects on cell
\ngrowth is crucial for rapid recovery from stress-induced quiescence.
\nResults: Prompted by qualitative modeling of the nutrient starvation
\nresponse in yeast, we investigated in vivo the effect of proteolysis
\nafter nutrient starvation showing that, for the Gis1 transcription factor
\nat least, proteasome-mediated control is crucial for a rapid return
\nto growth. Additional bioinformatics analyses show that potentially
\ntoxic transcriptional regulators have a significantly lower protein halflife,
\na higher fraction of unstructured regions and more potential
\nPEST motifs than the non-detrimental ones. Furthermore, inhibiting
\nproteasome activity tends to increase the expression of genes
\ninduced during the Environmental Stress Response more than those
\nin the rest of the genome. Our combined results suggest that
\nproteasome-mediated proteolysis of potentially toxic transcription
\nfactors tightly modulates the stress response in yeast.<\/p>\n","protected":false},"excerpt":{"rendered":"
Motivation: The appropriate modulation of the stress response to variable environmental conditions is necessary to maintain sustained viability in Saccharomyces cerevisiae. Particularly, controlling the abundance of proteins that may have detrimental effects on cell growth is crucial for rapid recovery from stress-induced quiescence. 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