{"id":165312,"date":"2013-10-01T00:00:00","date_gmt":"2013-10-01T00:00:00","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/msr-research-item\/biocharts-unifying-biological-hypotheses-with-models-and-experiments\/"},"modified":"2018-10-16T21:59:11","modified_gmt":"2018-10-17T04:59:11","slug":"biocharts-unifying-biological-hypotheses-with-models-and-experiments","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/biocharts-unifying-biological-hypotheses-with-models-and-experiments\/","title":{"rendered":"Biocharts: Unifying Biological Hypotheses with Models and Experiments"},"content":{"rendered":"<div class=\"asset-content\">\n<p>Understanding how biological systems develop and function remains one of the main open scientific challenges of our times. An improved quantitative understanding of biological systems, assisted by computational models is also important for future bioengineering and biomedical applications. We present a computational approach aimed towards unifying hypotheses with models and experiments, allowing to formally represent what a biological system does (specification) how it does it (mechanism) and systematically compare to data characterizing system behavior (experiments). We describe our Biocharts framework geared towards supporting this approach and illustrate its application in several biological domains including bacterial colony growth, developmental biology, and stem cell population dynamics.<\/p>\n<\/div>\n<p><!-- .asset-content --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Understanding how biological systems develop and function remains one of the main open scientific challenges of our times. An improved quantitative understanding of biological systems, assisted by computational models is also important for future bioengineering and biomedical applications. We present a computational approach aimed towards unifying hypotheses with models and experiments, allowing to formally represent [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":[{"type":"user_nicename","value":"hkugler"}],"msr_publishername":"IEEE","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"IEEE 9th International Conference on e-Science","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"","msr_journal":"","msr_number":"","msr_organization":"","msr_pages_string":"","msr_page_range_start":"","msr_page_range_end":"","msr_series":"","msr_volume":"","msr_copyright":"","msr_conference_name":"IEEE 9th International Conference on e-Science","msr_doi":"","msr_arxiv_id":"","msr_s2_paper_id":"","msr_mag_id":"","msr_pubmed_id":"","msr_other_authors":"","msr_other_contributors":"","msr_speaker":"","msr_award":"","msr_affiliation":"","msr_institution":"","msr_host":"","msr_version":"","msr_duration":"","msr_original_fields_of_study":"","msr_release_tracker_id":"","msr_s2_match_type":"","msr_citation_count_updated":"","msr_published_date":"2013-10-01","msr_highlight_text":"","msr_notes":"","msr_longbiography":"","msr_publicationurl":"","msr_external_url":"","msr_secondary_video_url":"","msr_conference_url":"","msr_journal_url":"","msr_s2_pdf_url":"","msr_year":2013,"msr_citation_count":0,"msr_influential_citations":0,"msr_reference_count":0,"msr_s2_match_confidence":0,"msr_microsoftintellectualproperty":true,"msr_s2_open_access":false,"msr_s2_author_ids":[],"msr_pub_ids":[],"msr_hide_image_in_river":0,"footnotes":""},"msr-research-highlight":[],"research-area":[13553],"msr-publication-type":[193716],"msr-publisher":[],"msr-focus-area":[],"msr-locale":[268875],"msr-post-option":[],"msr-field-of-study":[],"msr-conference":[],"msr-journal":[],"msr-impact-theme":[],"msr-pillar":[],"class_list":["post-165312","msr-research-item","type-msr-research-item","status-publish","hentry","msr-research-area-medical-health-genomics","msr-locale-en_us"],"msr_publishername":"IEEE","msr_edition":"IEEE 9th International Conference on e-Science","msr_affiliation":"","msr_published_date":"2013-10-01","msr_host":"","msr_duration":"","msr_version":"","msr_speaker":"","msr_other_contributors":"","msr_booktitle":"","msr_pages_string":"","msr_chapter":"","msr_isbn":"","msr_journal":"","msr_volume":"","msr_number":"","msr_editors":"","msr_series":"","msr_issue":"","msr_organization":"","msr_how_published":"","msr_notes":"","msr_highlight_text":"","msr_release_tracker_id":"","msr_original_fields_of_study":"","msr_download_urls":"","msr_external_url":"","msr_secondary_video_url":"","msr_longbiography":"","msr_microsoftintellectualproperty":1,"msr_main_download":"218167","msr_publicationurl":"","msr_doi":"","msr_publication_uploader":[{"type":"file","title":"eScience13.pdf","viewUrl":"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2013\/10\/eScience13.pdf","id":218167,"label_id":0}],"msr_related_uploader":"","msr_citation_count":0,"msr_citation_count_updated":"","msr_s2_paper_id":"","msr_influential_citations":0,"msr_reference_count":0,"msr_arxiv_id":"","msr_s2_author_ids":[],"msr_s2_open_access":false,"msr_s2_pdf_url":null,"msr_attachments":[{"id":218167,"url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2013\/10\/eScience13.pdf"}],"msr-author-ordering":[{"type":"user_nicename","value":"hkugler","user_id":32012,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=hkugler"}],"msr_impact_theme":[],"msr_research_lab":[],"msr_event":[],"msr_group":[],"msr_project":[544545],"publication":[],"video":[],"msr-tool":[],"msr_publication_type":"inproceedings","related_content":{"projects":[{"ID":544545,"post_title":"Station B","post_name":"stationb","post_type":"msr-project","post_date":"2019-03-11 15:56:07","post_modified":"2021-09-28 09:10:36","post_status":"publish","permalink":"https:\/\/www.microsoft.com\/en-us\/research\/project\/stationb\/","post_excerpt":"Our work on the Station B project has now been retired. We continue to actively explore the exciting intersection of computing and life sciences, with other projects located on\u00a0www.microsoft.com\/research. Building a platform for programming biology The ability to program biology could enable fundamental breakthroughs across a broad range of industries, including medicine, agriculture, food, construction, textiles, materials and chemicals. It could also help lay the foundation for a future bioeconomy based on sustainable technology. 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