{"id":343133,"date":"2016-12-29T12:09:29","date_gmt":"2016-12-29T20:09:29","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-research-item&#038;p=343133"},"modified":"2018-10-16T21:35:46","modified_gmt":"2018-10-17T04:35:46","slug":"molecular-switch-immunodominant-hiv-1-specific-cd8-t-cell-epitopes-shapes-differential-hla-restricted-escape","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/molecular-switch-immunodominant-hiv-1-specific-cd8-t-cell-epitopes-shapes-differential-hla-restricted-escape\/","title":{"rendered":"A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape"},"content":{"rendered":"<div id=\"ASec1\" class=\"AbstractSection\">\n<p id=\"Par1\" class=\"Para\">Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain unknown.<\/p>\n<\/div>\n<div id=\"ASec2\" class=\"AbstractSection\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain 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