{"id":443817,"date":"2017-11-29T06:07:16","date_gmt":"2017-11-29T14:07:16","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-research-item&#038;p=443817"},"modified":"2018-10-16T20:05:17","modified_gmt":"2018-10-17T03:05:17","slug":"nonparametric-bayesian-biclustering","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/nonparametric-bayesian-biclustering\/","title":{"rendered":"Nonparametric Bayesian Biclustering"},"content":{"rendered":"<p>We present a probabilistic block-constant biclustering model that simultaneously clusters<br \/>\nrows and columns of a data matrix. All entries with the same row cluster and column cluster<br \/>\nform a bicluster. Each cluster is part of a mixture having a nonparametric Bayesian prior. The<br \/>\nnumber of biclusters is therefore treated as a nuisance parameter and is implicitly integrated<br \/>\nover during simulation. Missing entries are completely integrated out of the model, allowing<br \/>\nus to completely bipass the common requirement for biclustering algorithms that missing<br \/>\nvalues be filled before analysis, but also makes it robust to high rates of missing values. By<br \/>\nusing a Gaussian model for the density of entries in bliclusters, an efficient sampling algorithm<br \/>\nis produced because bicluster parameters are analytically integrated out. We present<br \/>\nseveral inference procedures for sampling cluster indicators, including Gibbs and split-merge<br \/>\nmoves. We show that our method is competitive, if not superior, to existing imputation methods,<br \/>\nespecially for high missing rates, despite imputing constant values for entire blocks of<br \/>\ndata. We present imputation experiments and exploratory biclustering results.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We present a probabilistic block-constant biclustering model that simultaneously clusters rows and columns of a data matrix. All entries with the same row cluster and column cluster form a bicluster. Each cluster is part of a mixture having a nonparametric Bayesian prior. The number of biclusters is therefore treated as a nuisance parameter and is [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":null,"msr_publishername":"Department of Computer Science, University of Toronto","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"UTML TR 2007\u2013001","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"","msr_journal":"","msr_number":"UTML TR 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