{"id":675915,"date":"2020-07-17T08:00:23","date_gmt":"2020-07-17T15:00:23","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-research-item&#038;p=675915"},"modified":"2021-03-12T15:52:29","modified_gmt":"2021-03-12T23:52:29","slug":"a-machine-learning-approach-to-understanding-patterns-of-engagement-with-internet-delivered-mental-health-interventions","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/a-machine-learning-approach-to-understanding-patterns-of-engagement-with-internet-delivered-mental-health-interventions\/","title":{"rendered":"A Machine Learning Approach to Understanding Patterns of Engagement With Internet-Delivered Mental Health Interventions."},"content":{"rendered":"<p><strong>Importance<\/strong>\u00a0\u00a0The mechanisms by which engagement with internet-delivered psychological interventions are associated with depression and anxiety symptoms are unclear.<\/p>\n<p><strong>Objective<\/strong>\u00a0\u00a0To identify behavior types based on how people engage with an internet-based cognitive behavioral therapy (iCBT) intervention for symptoms of depression and anxiety.<\/p>\n<p><strong>Design, Setting, and Participants<\/strong>\u00a0\u00a0Deidentified data on 54\u202f604 adult patients assigned to the Space From Depression and Anxiety treatment program from January 31, 2015, to March 31, 2019, were obtained for probabilistic latent variable modeling using machine learning techniques to infer distinct patient subtypes, based on longitudinal heterogeneity of engagement patterns with iCBT.<\/p>\n<p><strong>Interventions<\/strong>\u00a0\u00a0A clinician-supported iCBT-based program that follows clinical guidelines for treating depression and anxiety, delivered on a web 2.0 platform.<\/p>\n<p><strong>Main Outcomes and Measures<\/strong>\u00a0\u00a0Log data from user interactions with the iCBT program to inform engagement patterns over time. Clinical outcomes included symptoms of depression (Patient Health Questionnaire-9 [PHQ-9]) and anxiety (Generalized Anxiety Disorder-7 [GAD-7]); PHQ-9 cut point greater than or equal to 10 and GAD-7 scores greater than or equal to 8 were used to define depression and anxiety.<\/p>\n<p><strong>Results<\/strong>\u00a0\u00a0Patients spent a mean (SD) of 111.33 (118.92) minutes on the platform and completed 230.60 (241.21) tools. At baseline, mean PHQ-9 score was 12.96 (5.81) and GAD-7 score was 11.85 (5.14). Five subtypes of engagement were identified based on patient interaction with different program sections over 14 weeks: class 1 (low engagers, 19\u202f930 [36.5%]), class 2 (late engagers, 11\u202f674 [21.4%]), class 3 (high engagers with rapid disengagement, 13\u202f936 [25.5%]), class 4 (high engagers with moderate decrease, 3258 [6.0%]), and class 5 (highest engagers, 5799 [10.6%]). Estimated mean decrease (SE) in PHQ-9 score was 6.65 (0.14) for class 3, 5.88 (0.14) for class 5, and 5.39 (0.14) for class 4; class 2 had the lowest rate of decrease at \u22124.41 (0.13). Compared with PHQ-9 score decrease in class 1, the Cohen\u00a0<i>d<\/i>\u00a0effect size (SE) was \u22120.46 (0.014) for class 2, \u22120.46 (0.014) for class 3, \u22120.61 (0.021) for class 4, and \u22120.73 (0.018) for class 5. Similar patterns were found across groups for GAD-7.<\/p>\n<p><strong>Conclusions and Relevance<\/strong>\u00a0\u00a0The findings of this study may facilitate tailoring interventions according to specific subtypes of engagement for individuals with depression and anxiety. Informing clinical decision needs of supporters may be a route to successful adoption of machine learning insights, thus improving clinical outcomes overall.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance\u00a0\u00a0The mechanisms by which engagement with internet-delivered psychological interventions are associated with depression and anxiety symptoms are unclear. Objective\u00a0\u00a0To identify behavior types based on how people engage with an internet-based cognitive behavioral therapy (iCBT) intervention for symptoms of depression and anxiety. Design, Setting, and Participants\u00a0\u00a0Deidentified data on 54\u202f604 adult patients assigned to the Space From [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":null,"msr_publishername":"","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"7","msr_journal":"JAMA Network","msr_number":"","msr_organization":"","msr_pages_string":"","msr_page_range_start":"","msr_page_range_end":"","msr_series":"","msr_volume":"3","msr_copyright":"This is an open access article distributed under the terms of the CC-BY-NC-ND License. \u00a9 2020 Chien I et al. 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