Many modern sequence alignment tools implement fast string matching using the space efficient data structure called a FM-index. The succinct nature of this data structure presents unique challenges for the algorithm designers. In this paper, we explore the opportunities for parallelization of the exact and inexact matches, and present an efficient solution for the Occ portion of the algorithm that utilizes the instruction-level parallelism of the modern CPUs. Our implementation computes all eight Occ values required for the inexact match algorithm step in a single pass. We showcase the algorithm performance in a multi-core genome aligner and discuss effects of the memory prefetch.<\/p>\n","protected":false},"excerpt":{"rendered":"
Many modern sequence alignment tools implement fast string matching using the space efficient data structure called a FM-index. The succinct nature of this data structure presents unique challenges for the algorithm designers. 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