{"id":814090,"date":"2022-01-19T16:06:05","date_gmt":"2022-01-20T00:06:05","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-research-item&p=814090"},"modified":"2022-01-19T16:06:05","modified_gmt":"2022-01-20T00:06:05","slug":"parameters-of-chronic-kidney-disease-to-identify-outpatients-at-increased-risk-for-covid-19-mortality-a-cohort-study-of-uk-biobank-participants","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/parameters-of-chronic-kidney-disease-to-identify-outpatients-at-increased-risk-for-covid-19-mortality-a-cohort-study-of-uk-biobank-participants\/","title":{"rendered":"Parameters of Chronic Kidney Disease to Identify Outpatients at Increased Risk for COVID-19 Mortality: A Cohort Study of UK Biobank Participants"},"content":{"rendered":"

Coronavirus Disease (COVID-19) has resulted in a pandemic affecting more than a hundred countries worldwide [1 (opens in new tab)<\/span><\/a><\/span>]. Limited worldwide supply of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV) requires policymakers to prioritize high-risk populations for inoculation. Several clinical risk factors have been suggested to increase infection risk [2 (opens in new tab)<\/span><\/a><\/span>]. However, it is less well-known how pre-morbid, outpatient clinical variables influence COVID-19 risk of death. We retrospectively analyzed outpatient risk factors for death in the UK Biobank (UKBB), a large-scale prospective cohort comprising over 500,000 subjects aged 40-69 years recruited in 2006-2019 [3 (opens in new tab)<\/span><\/a><\/span>]. In this study, subjects with recorded mortality before 31st<\/sup>\u00a0January 2020 (N = 28,930) were excluded since it was the date for the first recorded COVID-19 case in the UK. We performed a comprehensive study on primary care data and their associations with COVID-19 mortality in UKBB, controlling for possible confounding factors. To our knowledge, this is the broadest analysis of outpatient clinical factors and associations with COVID-19 to date.<\/p>\n","protected":false},"excerpt":{"rendered":"

Coronavirus Disease (COVID-19) has resulted in a pandemic affecting more than a hundred countries worldwide [1]. Limited worldwide supply of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV) requires policymakers to prioritize high-risk populations for inoculation. Several clinical risk factors have been suggested to increase infection risk [2]. However, it is less well-known how […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":null,"msr_publishername":"","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"","msr_journal":"The Open Urology & Nephrology Journal","msr_number":"","msr_organization":"","msr_pages_string":"","msr_page_range_start":"","msr_page_range_end":"","msr_series":"","msr_volume":"","msr_copyright":"","msr_conference_name":"","msr_doi":"","msr_arxiv_id":"","msr_s2_paper_id":"","msr_mag_id":"","msr_pubmed_id":"","msr_other_authors":"","msr_other_contributors":"","msr_speaker":"","msr_award":"","msr_affiliation":"","msr_institution":"","msr_host":"","msr_version":"","msr_duration":"","msr_original_fields_of_study":"","msr_release_tracker_id":"","msr_s2_match_type":"","msr_citation_count_updated":"","msr_published_date":"2021-12","msr_highlight_text":"","msr_notes":"","msr_longbiography":"","msr_publicationurl":"","msr_external_url":"","msr_secondary_video_url":"","msr_conference_url":"","msr_journal_url":"","msr_s2_pdf_url":"","msr_year":0,"msr_citation_count":0,"msr_influential_citations":0,"msr_reference_count":0,"msr_s2_match_confidence":0,"msr_microsoftintellectualproperty":true,"msr_s2_open_access":false,"msr_s2_author_ids":[],"msr_pub_ids":[],"msr_hide_image_in_river":0,"footnotes":""},"msr-research-highlight":[],"research-area":[13553],"msr-publication-type":[193715],"msr-publisher":[],"msr-focus-area":[],"msr-locale":[268875],"msr-post-option":[],"msr-field-of-study":[],"msr-conference":[],"msr-journal":[],"msr-impact-theme":[],"msr-pillar":[],"class_list":["post-814090","msr-research-item","type-msr-research-item","status-publish","hentry","msr-research-area-medical-health-genomics","msr-locale-en_us"],"msr_publishername":"","msr_edition":"","msr_affiliation":"","msr_published_date":"2021-12","msr_host":"","msr_duration":"","msr_version":"","msr_speaker":"","msr_other_contributors":"","msr_booktitle":"","msr_pages_string":"","msr_chapter":"","msr_isbn":"","msr_journal":"The Open Urology & Nephrology Journal","msr_volume":"","msr_number":"","msr_editors":"","msr_series":"","msr_issue":"","msr_organization":"","msr_how_published":"","msr_notes":"","msr_highlight_text":"","msr_release_tracker_id":"","msr_original_fields_of_study":"","msr_download_urls":"","msr_external_url":"","msr_secondary_video_url":"","msr_longbiography":"","msr_microsoftintellectualproperty":1,"msr_main_download":"","msr_publicationurl":"","msr_doi":"","msr_publication_uploader":[{"type":"url","viewUrl":"false","id":"false","title":"https:\/\/openurologyandnephrologyjournal.com\/VOLUME\/14\/PAGE\/26\/FULLTEXT\/","label_id":"243109","label":0},{"type":"doi","viewUrl":"false","id":"false","title":"10.2174\/1874303X02114010026","label_id":"243109","label":0}],"msr_related_uploader":"","msr_citation_count":0,"msr_citation_count_updated":"","msr_s2_paper_id":"","msr_influential_citations":0,"msr_reference_count":0,"msr_arxiv_id":"","msr_s2_author_ids":[],"msr_s2_open_access":false,"msr_s2_pdf_url":null,"msr_attachments":[],"msr-author-ordering":[{"type":"user_nicename","value":"Anusua Trivedi","user_id":40732,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=Anusua Trivedi"},{"type":"text","value":"W. Conrad Liles","user_id":0,"rest_url":false},{"type":"guest","value":"nicholas-becker","user_id":775627,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=nicholas-becker"},{"type":"user_nicename","value":"Juan M. Lavista Ferres","user_id":39552,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=Juan M. Lavista Ferres"},{"type":"guest","value":"dr-aaron-lee","user_id":775597,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=dr-aaron-lee"},{"type":"guest","value":"dr-pavan-bhatraju","user_id":775591,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=dr-pavan-bhatraju"}],"msr_impact_theme":[],"msr_research_lab":[],"msr_event":[],"msr_group":[916890],"msr_project":[918249],"publication":[],"video":[],"msr-tool":[],"msr_publication_type":"article","related_content":{"projects":[{"ID":918249,"post_title":"Treatment & diagnostics","post_name":"treatment-diagnostics","post_type":"msr-project","post_date":"2023-10-25 20:49:14","post_modified":"2023-12-13 11:17:07","post_status":"publish","permalink":"https:\/\/www.microsoft.com\/en-us\/research\/project\/treatment-diagnostics\/","post_excerpt":"\"The T-Detect COVID Test is a novel technology that assesses the T cell immune response to COVID-19. Information and scientific data that deepen our understanding of SARS-CoV-2 remain important keys to get ahead of this global pandemic.\" In March 2020, Microsoft and Adaptive Biotechnologies expanded their existing collaboration to map and measure the immune response to multiple diseases and started applying their combined capabilities to COVID-19. In May, Adaptive started enrollment for a virtual clinical…","_links":{"self":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-project\/918249"}]}}]},"_links":{"self":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-research-item\/814090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-research-item"}],"about":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/types\/msr-research-item"}],"version-history":[{"count":1,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-research-item\/814090\/revisions"}],"predecessor-version":[{"id":814093,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-research-item\/814090\/revisions\/814093"}],"wp:attachment":[{"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/media?parent=814090"}],"wp:term":[{"taxonomy":"msr-research-highlight","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-research-highlight?post=814090"},{"taxonomy":"msr-research-area","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/research-area?post=814090"},{"taxonomy":"msr-publication-type","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-publication-type?post=814090"},{"taxonomy":"msr-publisher","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-publisher?post=814090"},{"taxonomy":"msr-focus-area","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-focus-area?post=814090"},{"taxonomy":"msr-locale","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-locale?post=814090"},{"taxonomy":"msr-post-option","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-post-option?post=814090"},{"taxonomy":"msr-field-of-study","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-field-of-study?post=814090"},{"taxonomy":"msr-conference","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-conference?post=814090"},{"taxonomy":"msr-journal","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-journal?post=814090"},{"taxonomy":"msr-impact-theme","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-impact-theme?post=814090"},{"taxonomy":"msr-pillar","embeddable":true,"href":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/wp\/v2\/msr-pillar?post=814090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}