Jeffrey Combs has spent most of his screen career in horror and science fiction films. Fans of those genres are most readily familiar with Combs for his portrayal of enterprising medical student Herbert West in the Re-Animator films. Both were based on the works of H.P. Lovecraft, whom Combs portrayed in Necronomicon (1993). Often as not, the names of Jeffrey Combs' screen characters are prefixed with the designation "doctor": Dr. Jones in The Man With Two Brains (1982), Dr. East in The Guyver (1991), and the title character in Doctor Mordrid (1992).