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Trojan:WinNT/Sirefef.N is a component of Win32/Sirefef - a multi-component family of malware that moderates your Internet experience by changing search results and generating pay-per-click advertising revenue for its controllers. The family consists of multiple parts that perform different functions, such as downloading updates and additional components, hiding existing components, or performing a payload.
Note: This Sirefef variant has been observed using specific ports for its peer-to-peer communications. We strongly encourage you to block access to the following ports to limit Sirefef’s communication channels and prevent additional Sirefef components being downloaded:
You can read more about how to block access to a port in this article: http://support.microsoft.com/kb/813878