After a rough break-up, Elizabeth (played by songstress Norah Jones in her screen debut) sets out on a journey across America, leaving behind a life of memories, a dream and a soulful new friend – a café owner (Jude Law) – all while in search of something to mend her broken heart. Waitressing her way through the country, Elizabeth befriends others whose yearnings are greater than hers, including a troubled cop (David Strathairn) and his estranged wife (Rachel Weisz) and a down-on-her luck gambler (Natalie Portman) with a score to settle. Through these individuals, Elizabeth witnesses the true depths of loneliness and emptiness, and begins to understand that her own journey is part of a greater exploration within herself.