Six school friends meet up for a fourth of July celebration on a remote island for a drug-fuelled weekend. What they don't know is the drugs they scored are not what they seem; it's actually a new bioactive compound peddled by a sadistic right-wing terrorist organisation. Anyone consuming it is then exposed to a virus causing fits of psychotic rage, mind-bending chaos and cannibalistic murder. Only one refused to partake and now she must fight to survive as everyone around her, including her fiancé, tries to savagely kill her.