In Ghostbusters, when New York City's ghosts go on a rampage, three out-of-work parapsychologists team up to save the Big Apple. In Ghostbusters II, The Ghostbusters return with twice the know-how and twice the particle power to save the world again. Ghostbusters: Afterlife comes from director Jason Reitman and producer Ivan Reitman, the third chapter in the original Ghostbusters universe.