As a viral pandemic spreads across America, Wade Vogel (ARNOLD SCHWARZENEGGER) searches for his runaway daughter Maggie (ABIGAIL BRESLIN) and finds her in the quarantine wing of a hospital. Wade brings his daughter back home to his family for the short time before the teenager begins a painful metamorphosis. Determined to hold onto his precious daughter as long as he can and refusing to hand her over to the local police, Wade edges ever closer to a time where he will have to take matters into his own hands.