Based on the comic book created by Jimmy Palmiotti and Joe Quesada, Painkiller Jane is the story of Jane Vasco (KRISTANNA LOKEN), a DEA agent who is recruited by a covert government organization tasked with capturing “Neuros” – genetically-enhanced individuals who possess superhuman powers of the mind. During the course of her first investigation with the team, Jane inexplicably discovers that she too possesses extraordinary abilities – abilities that render her impervious to injury…but not pain. She develops miraculous regenerative powers, healing from every injury and finding herself stronger than she had been before. As she continues to work with the government to hunt Neuros, Jane tries to uncover the cause of her own transformation and what – if any – connection she shares with the very people she is pursuing.