They Say It Can't Be Done follows four companies on the cutting edge of breakthrough solutions to some of humanity's most pressing problems. Josh Tetrick and his team at JUST use cell culture technology to sustainably create real animal protein without killing a single animal. Dr. Anthony Atala's organic 3D printing technology revolutionizes healthcare from a system of treatment to a system of cures, forever eliminating the organ waitlist. Dr. Klaus Lackner's plastic "trees" remove atmospheric carbon at a thousand times the rate of an organic tree. Catalina Sea Ranch, the first open ocean farm, produces sustainable, organic food while de-acidifying the sea. Each innovator in the film has the potential to solve some of our greatest challenges, but all face a common roadblock: an outdated regulatory system impeding their pathways to success.