Issue 1: Introduction
Frontier organizations are redefining how work gets done, with humans and agents operating side-by-side to elevate human ambition. Recent Microsoft data indicates that these human-agent teams are growing and becoming widely adopted globally.
AI agents are scaling faster than some companies can see them and that visibility gap is a business risk. Organizations urgently need effective governance and security to safely adopt agents, promote innovation, and reduce risk. Like human users, AI agents require protection through observability, governance, and strong security using Zero Trust principles. Enterprises succeeding in the next phase of AI adoption will be those that move with speed and bring business, IT, security, and developer teams together to observe, govern, and secure their AI transformation.
Across Microsoft’s ecosystem, customers are now building and deploying agents on every major platform—from Fabric and Foundry to Copilot Studio and Agent Builder—reflecting a broad shift toward AI-powered automation in the flow of work.
Agent building isn't limited to technical roles; today employees in various positions create and use agents in daily work. In fact, Microsoft data shows that over 80% of the Fortune 500 is deploying active agents built with low-code/no-code tools.1 With agent use expanding and transformation opportunities multiplying, now is the time to get foundational controls in place.
Just like for human employees, Zero Trust for agents means:
Least privilege access: Give every user, AI agent, or system only what they need—no more.
Explicit verification: Always confirm who or what is requesting access using identity, device health, location, risk level.
Assume compromise can occur: Design systems expecting that attackers will get inside.
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