Microsoft 365 E5 is a comprehensive enterprise subscription that combines productivity, identity, device, and security capabilities in one license. In addition to Microsoft Security, it includes Microsoft 365 Apps, Exchange, SharePoint, Teams, advanced compliance, and identity protection.
Microsoft Defender Suite is a security focused on threat protection and detection and response across endpoints, identities, email, and SaaS apps. It delivers Microsoft Defender capabilities without the productivity or compliance services included in Microsoft 365 E5.
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