Simulation of the reformulated sequences bypassing the existing filters undetected, prior to the red-teaming patch.

Paraphrase Project

News & features

Illustrated headshots (from left to right): Eric Horvitz, Bruce Wittmann, Tessa Alexanian, and James Diggans.
Microsoft Research Podcast

| Eric Horvitz, Bruce Wittmann, Tessa Alexanian, and James Diggans

Microsoft’s Eric Horvitz and guests Bruce Wittmann, Tessa Alexanian, and James Diggans discuss the Paraphrase Project—a red-teaming effort that exposed and secured a biosecurity vulnerability in AI-driven protein design. The work offers a model for addressing AI’s dual-use risks.

Paraphrase Project Protiens
Microsoft Research Blog

| Eric Horvitz

Microsoft researchers reveal a confidential research effort that explored how open-source AI tools could be used to bypass biosecurity checks—and helped create fixes now influencing global standards.