Computer science as an academic discipline began in the 60’s. Emphasis was on programming languages, compilers, operating systems, and the mathematical theory that supported these areas. Courses in theoretical computer science covered nite automata, regular expressions, context free languages, and computability. In the 70’s, algorithms was added as an important component of theory. The emphasis was on making computers useful. Today, a fundamental change is taking place and the focus is more on applications. There are many reasons for this change. The merging of computing and communications has played an important role. The enhanced ability to observe, collect and store data in the natural sciences, in commerce, and in other elds calls for a change in our understanding of data and how to handle it in the modern setting. The emergence of the web and social networks, which are by far the largest such structures, presents both opportunities and challenges for theory.