Artificial Intelligence
Pursuing computing advances to create intelligent machines that complement human reasoning to augment and enrich our experience and competencies.
Project
Small molecules
Bringing scale, speed, and precision to molecular discovery with AI We work on accelerating the discovery of small molecules through AI at all steps of the Design-Make-Test cycle. This includes models to predict molecular properties,…
Project
Psychological influences of AI
The Psychological Influences of AI (Psi) project explores how AI—especially generative AI—affects human psychology, including cognition, emotion, behavior, and well-being. It investigates topics such as trust, dependency, attention, agency, and the psychological impacts of anthropomorphic…
Video
Evaluating the Cultural Relevance of AI Models and Products: Learnings on Maternal Health ASR, Data Augmentation and User Testing Methods
How do we ensure that AI systems are not only technologically advanced but also deeply resonant and beneficial for the specific communities they aim to serve? As AI becomes more integrated into critical sectors like…
Event
COLM 2025
Microsoft is proud to be a sponsor of the Conference on Language Models (COLM (opens in new tab)), an academic venue dedicated to advancing the study of language modeling. COLM brings together researchers from diverse…
Podcast
Ideas: More AI-resilient biosecurity with the Paraphrase Project
Microsoft’s Eric Horvitz and guests Bruce Wittmann, Tessa Alexanian, and James Diggans discuss the Paraphrase Project—a red-teaming effort that exposed and secured a biosecurity vulnerability in AI-driven protein design. The work offers a model for…
Microsoft Research Blog
When AI Meets Biology: Promise, Risk, and Responsibility
Microsoft researchers reveal a confidential research effort that explored how open-source AI tools could be used to bypass biosecurity checks—and helped create fixes now influencing global standards.
Project
Paraphrase Project
The Paraphrase Project addresses a critical and emerging risk: as generative AI and synthetic biology advance, there is a growing possibility that open-source AI tools could be misused to design biological toxins that evade current…