HIV Vaccine Design

HIV is one of the world’s primary health concerns.  Researchers at Microsoft are collaborating with leading HIV scientific centers to bring together research expertise and cutting-edge computing technology in to the fight against the virus.  Computational tools are available here (opens in new tab).

In the news

Washington Post, 2016 (opens in new tab)

Geek Wire, 2013 (opens in new tab)

Fast Company, 2012 (opens in new tab)

Microsoft Blog, 2011 (opens in new tab)

Selected references

F. Pereyra, D. Heckerman, J. Carlson, C. Kadie, D. Soghoian, D. Karel, A. Goldenthal, O. Davis, C. DeZiel, T. Lin, J. Peng, A. Piechocka, M. Carrington, and B. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes (opens in new tab). J. Virol 88 12937-12948, Aug 2014.

J. Carlson, M. Schaefer, D. Monaco, R. Batorsky, D. Claiborne, J. Prince, M. Deymier, Z. Ende, N. Klatt, C. DeZiel, Tien-Ho Lin, J. Peng, A. Seese, R. Shapiro, J. Frater, T. Ndung’u, J. Tang, P. Goepfert, J. Gilmour, M. Price, W. Kilembe, D. Heckerman, P. Goulder, T. Allen, S. Allen, and E. Hunter. Selection bias at the heterosexual HIV-1 transmission bottleneck (opens in new tab). Science, 345(6193): 1254031, July 2014 (doi:10.1126/science.1254031).

R. Rubsamen, C. Herst, P. Lloyd, D. Heckerman. Eliciting cytotoxic T-lymphocyte responses from synthetic vectors containing one or two epitopes in a C57BL/6 mouse model using peptide-containing biodegradable microspheres and adjuvants (opens in new tab). Vaccine 32, 4111-4116, June 2014.