Whole-Organism Model of C. Elegans Development

Established: January 6, 2013

The nematode C. elegans, with its invariant lineage, serves as a model organism for the study of development. We aim to create an open-source, extensible whole-organism model of C. elegans development to which the worm community can add new information. In the first stage of this project we use this simulation program to study developmental variance in C. elegans, and in particular how this may arise through perturbations in cell-cycle timing. This early version of the model is used to provide new insights into embryogenesis under environmental stress, and into cell signalling through cell-cycle timing constraints.