Lack of Association between HLA Class II Alleles and In Vitro Replication Capacities of Recombinant Viruses Encoding HIV-1 Subtype C Gag-Protease from Chronically Infected Individuals

  • Jaclyn K. Wright ,
  • Zabrina L. Brumme ,
  • Boris Julg ,
  • Mary van der Stok ,
  • Zenele Mncube ,
  • Xiaojiang Gao ,
  • ,
  • Philip J. R. Goulder ,
  • Bruce D. Walker ,
  • Mark A. Brockman ,
  • Thumbi Ndung'u

Journal of Virology |

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It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles and lower replication capacity, suggesting no significant HIV-1 attenuation by HLA class II-restricted Gag-specific CD4+ T cell immune pressure.