We created Asthma e-Lab, a secureweb-based research environmentto support consistent recording, description and sharing of data, computational/statistical methods and emerging findings acrossthe five UK birth cohorts. The eLab serves as a datarepository forour unified dataset and providesthe computational resources and a scientific social network to support collaborative research. All activities are transparent, and emerging findings are shared viathe eLab, linkedto explanations ofanalytical methods,thus enablingknowledge transfer. eLab facilitatesthe iterative interdisciplinary dialoguebetween clinicians, statisticians, computer scientists, mathematicians, geneticists and basic scientists, capturing collective thought behindthe interpretations of findings.