Artificial Intelligence
Pursuing computing advances to create intelligent machines that complement human reasoning to augment and enrich our experience and competencies.
Event
COLM 2025
Microsoft is proud to be a sponsor of the Conference on Language Models (COLM (opens in new tab)), an academic venue dedicated to advancing the study of language modeling. COLM brings together researchers from diverse…
Podcast
Ideas: More AI-resilient biosecurity with the Paraphrase Project
Microsoft’s Eric Horvitz and guests Bruce Wittmann, Tessa Alexanian, and James Diggans discuss the Paraphrase Project—a red-teaming effort that exposed and secured a biosecurity vulnerability in AI-driven protein design. The work offers a model for…
Microsoft Research Blog
When AI Meets Biology: Promise, Risk, and Responsibility
Microsoft researchers reveal a confidential research effort that explored how open-source AI tools could be used to bypass biosecurity checks—and helped create fixes now influencing global standards.
Project
Paraphrase Project
The Paraphrase Project addresses a critical and emerging risk: as generative AI and synthetic biology advance, there is a growing possibility that open-source AI tools could be misused to design biological toxins that evade current…
Tool
RetroChimera
RetroChimera is a model that takes as input a target molecule that one wants to synthesize, encoded as a sequence of characters (using the SMILES notation), and produces several potential chemical reactions which could be…