Portrait of Sara-Jane Dunn

Sara-Jane Dunn

Scientist

About

I am a scientist based in the Biological Computation group at Microsoft Research Cambridge, and an affiliate researcher at the Wellcome-MRC Stem Cell Institute, University of Cambridge. I completed my undergraduate and postgraduate training at the University of Oxford, first obtaining a Masters in Mathematics, followed by a DPhil in Computational Biology, based in the Department of Computer Science.

My research sits at the interface between mathematics, computer science and biology. More specifically, I focus on the concept of biology as computation, in which the biochemistry of the cell performs information processing in the service of decision-making. Towards this, I collaborate with experimentalists at the Universities of Cambridge and Padova to investigate stem cell decision-making throughout Development. As a computational scientist in biology, my goal is to identify the necessary abstractions to develop predictive, explanatory models of the biological programs that govern cellular behaviour. Ultimately, this research will lead us to make cells programmable, which could fundamentally transform medicine, agriculture and even the ways we generate energy.

Collaborators

Prof Austin Smith, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge
Dr Graziano Martello, Department of Molecular Medicine, University of Padua
Prof Inke Nathke, School of Life Sciences, University of Dundee
Dr Hillel Kugler, Faculty of Engineering, Bar-Ilan University

Press

Forbes: Future tech
17 for ’17: Microsoft researchers on what to expect in 2017 and 2027
Development: Quantitative stem cell biology: the threat and the glory
#MakeWhatsNext: Girls in Tech Europe
New Scientist: Windows bug-testing software cracks stem cell programs
The Scientist: Minimal toolkit for stem cell self-renewal
Inside Microsoft Research: Theorem prover sheds new light on stem cell behaviour
Womanthology: Banishing imposter syndrome

 

Projects

Publications

Videos

Other

Biography

I studied Mathematics at the University of Oxford, graduating with an MMath in 2007. During the summer of 2006 I completed a NERC internship at the British Antarctic Survey, working with Dr. Andrew Edwards on the foraging behaviour of the wandering albatross.

I began my DPhil. in 2007, also at Oxford, as a student of the Life Science Interface Doctoral Training Centre (DTC). The first year of my doctoral studies was spent completing an intensive training course coordinated by the DTC in the application of mathematical, physical, computational and engineering science techniques to the biomedical and life sciences. At the end of this year, I joined the Computational Biology group to begin my DPhil. research project, supervised by Prof. David Gavaghan, Prof. Helen Byrne, Prof. Jon Chapman and Dr. James Osborne. The focus of this project was the development of a computational model of the intestinal crypt, to facilitate investigation of the initial stages of carcinogenesis which precede colorectal cancer. I completed my DPhil. in December 2010, just prior to joining Microsoft Research as a postdoctoral researcher. In June 2014 I became a permanent member of the Biological Computation group.