Portrait of Sara-Jane Dunn

Sara-Jane Dunn

Scientist

About

I am a scientist based within the Biological Computation group at Microsoft Research Cambridge, and an affiliate researcher at the Wellcome Trust – Medical Research Council Stem Cell Institute, University of Cambridge. I am a mathematician, and received my doctoral degree from the Department of Computer Science, University of Oxford. I work at the interface between mathematics, computer science and biology.

Specifically, my research is centred on developing a theory of biology as computation, in which the biochemistry of the cell performs information processing in the service of decision-making. Towards this, I collaborate with researchers at MSR, and experimentalists at the Universities of Cambridge and Padova to investigate stem cell decision-making throughout Development. I seek to identify the necessary abstractions to develop predictive, explanatory models of biological behaviour. The goal of this research is ultimately to make cells programmable, which could fundamentally transform medicine, agriculture and even the ways we generate energy.

Collaborators

  • Prof Austin Smith, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge
    • Dr Amy Li, Smith lab
  • Dr Graziano Martello, Department of Molecular Medicine, University of Padua
  • Prof Inke Nathke, School of Life Sciences, University of Dundee
  • Dr Brian Hendrich, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge
    • Dr Nicola Reynolds, Hendrich lab
  • Dr James Osborne, School of Mathematics and Statistics, University of Melbourne

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Biography

I studied Mathematics at the University of Oxford, graduating with an MMath in 2007. During the summer of 2006 I completed a NERC internship at the British Antarctic Survey, working with Dr. Andrew Edwards on the foraging behaviour of the wandering albatross.

I began my DPhil. in 2007, also at Oxford, as a student of the Life Science Interface Doctoral Training Centre (DTC). The first year of my doctoral studies was spent completing an intensive training course coordinated by the DTC in the application of mathematical, physical, computational and engineering science techniques to the biomedical and life sciences. At the end of this year, I joined the Computational Biology group to begin my DPhil. research project, supervised by Prof. David Gavaghan, Prof. Helen Byrne, Prof. Jon Chapman and Dr. James Osborne. The focus of this project was the development of a computational model of the intestinal crypt, to facilitate investigation of the initial stages of carcinogenesis which precede colorectal cancer. I completed my DPhil. in December 2010, just prior to joining Microsoft Research as a postdoctoral researcher. In June 2014 I became a permanent member of the Biological Computation group.